Arsenic in PDB 1b92: Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

All present enzymatic activity of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity:
2.7.7.49;

The structure of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b92 was solved by J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 2.02
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	72.260, 72.260, 65.600, 90.00, 90.00, 120.00
R / Rfree (%)	22.5 / 28.9

The binding sites of Arsenic atom in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity (pdb code 1b92). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b92:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As300 b:34.6 occ:1.00 AS A:CAC300 0.0 34.6 1.0 O1 A:CAC300 1.3 40.1 1.0 C1 A:CAC300 2.2 34.9 1.0 SG A:CYS65 2.3 27.4 1.0 C2 A:CAC300 2.3 34.4 1.0 CB A:CYS65 3.2 27.9 1.0 OD1 A:ASN120 3.3 34.4 1.0 N A:CYS65 3.6 26.8 1.0 CG A:ASN120 3.6 33.4 1.0 ND2 A:ASN120 3.6 29.3 1.0 O A:HOH406 3.8 27.2 1.0 CA A:CYS65 3.9 28.3 1.0 O A:HOH439 4.0 54.7 1.0 OE2 A:GLU92 4.0 45.0 1.0 C A:ASP64 4.1 27.1 1.0 CG A:GLU92 4.2 43.8 1.0 CD A:GLU92 4.5 44.0 1.0 OG1 A:THR97 4.5 27.5 1.0 CB A:ASN120 4.6 32.3 1.0 CA A:ASP64 4.7 27.0 1.0 O A:ASP64 4.7 28.2 1.0 O A:HOH453 4.9 43.8 1.0 CG A:LEU74 4.9 33.9 1.0 O A:HOH407 5.0 31.3 1.0 O A:HOH424 5.0 47.0 1.0

Arsenic binding site 2 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As400 b:40.0 occ:1.00 AS A:CAC400 0.0 40.0 1.0 O1 A:CAC400 1.3 30.1 1.0 C2 A:CAC400 2.2 33.8 1.0 C1 A:CAC400 2.2 33.8 1.0 SG A:CYS130 2.3 25.3 1.0 CB A:CYS130 3.2 22.8 1.0 CG2 A:ILE135 4.3 25.4 1.0 CA A:CYS130 4.6 21.8 1.0 O A:ILE135 4.6 28.1 1.0 N A:GLN137 4.6 42.6 1.0 CG1 A:VAL126 4.6 25.1 1.0 CD2 A:PHE121 4.7 35.0 1.0 C A:LYS136 4.7 39.6 1.0 CG A:PHE121 4.8 33.9 1.0 CB A:GLN137 4.8 47.8 1.0 CA A:GLN137 4.8 47.7 1.0 CB A:ILE135 4.8 26.7 1.0 O A:LYS136 4.9 35.4 1.0 CD1 A:LEU101 5.0 24.9 1.0

J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe. The Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity. Biochemistry V. 38 8892 1999.
ISSN: ISSN 0006-2960
PubMed: 10413462
DOI: 10.1021/BI9907173