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Arsenic in PDB 1b9d: Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

Enzymatic activity of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

All present enzymatic activity of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity:
2.7.7.49;

Protein crystallography data

The structure of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9d was solved by J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 1.70
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 72.350, 72.350, 65.720, 90.00, 90.00, 120.00
R / Rfree (%) 22.4 / 27.8

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity (pdb code 1b9d). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9d:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1b9d

Go back to Arsenic Binding Sites List in 1b9d
Arsenic binding site 1 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As300

b:31.6
occ:1.00
AS A:CAC300 0.0 31.6 1.0
O1 A:CAC300 1.3 41.0 1.0
C1 A:CAC300 2.1 35.5 1.0
SG A:CYS65 2.2 25.8 1.0
C2 A:CAC300 2.3 36.4 1.0
CB A:CYS65 3.2 23.8 1.0
OD1 A:ASN120 3.5 34.0 1.0
N A:CYS65 3.5 23.2 1.0
ND2 A:ASN120 3.5 25.6 1.0
CG A:ASN120 3.7 31.3 1.0
CA A:CYS65 3.8 23.5 1.0
O A:HOH406 3.9 26.5 1.0
O A:HOH439 4.0 42.0 1.0
OE2 A:GLU92 4.0 39.1 1.0
C A:ASP64 4.1 27.0 1.0
CG A:GLU92 4.1 37.5 1.0
CD A:GLU92 4.5 37.6 1.0
OG1 A:THR97 4.5 25.5 1.0
CB A:ASN120 4.6 32.8 1.0
CA A:ASP64 4.6 24.9 1.0
O A:ASP64 4.7 25.4 1.0
O A:HOH456 4.9 37.5 1.0
CD1 A:LEU74 4.9 33.9 1.0
CG A:LEU74 5.0 34.0 1.0

Arsenic binding site 2 out of 2 in 1b9d

Go back to Arsenic Binding Sites List in 1b9d
Arsenic binding site 2 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As400

b:41.7
occ:1.00
AS A:CAC400 0.0 41.7 1.0
O1 A:CAC400 1.3 17.1 1.0
C2 A:CAC400 2.1 38.0 1.0
C1 A:CAC400 2.2 38.8 1.0
SG A:CYS130 2.2 24.7 1.0
CB A:CYS130 3.2 25.2 1.0
O A:HOH507 4.2 56.3 1.0
CG1 A:VAL126 4.4 23.6 1.0
CD2 A:PHE121 4.5 32.1 1.0
CG A:PHE121 4.5 30.2 1.0
CA A:CYS130 4.6 22.7 1.0
CB A:PHE121 4.7 27.6 1.0
CG2 A:ILE135 4.7 23.5 1.0
O A:VAL126 4.8 23.1 1.0
CD1 A:LEU101 4.8 28.1 1.0
CD1 A:PHE121 4.8 28.4 1.0
CE2 A:PHE121 4.9 33.1 1.0
O A:ILE135 4.9 24.1 1.0

Reference:

J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe. The Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity. Biochemistry V. 38 8892 1999.
ISSN: ISSN 0006-2960
PubMed: 10413462
DOI: 10.1021/BI9907173
Page generated: Tue Oct 27 16:46:06 2020

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