Arsenic in PDB 1b9d: Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

All present enzymatic activity of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity:
2.7.7.49;

The structure of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9d was solved by J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.70
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	72.350, 72.350, 65.720, 90.00, 90.00, 120.00
R / Rfree (%)	22.4 / 27.8

The binding sites of Arsenic atom in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity (pdb code 1b9d). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9d:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As300 b:31.6 occ:1.00 AS A:CAC300 0.0 31.6 1.0 O1 A:CAC300 1.3 41.0 1.0 C1 A:CAC300 2.1 35.5 1.0 SG A:CYS65 2.2 25.8 1.0 C2 A:CAC300 2.3 36.4 1.0 CB A:CYS65 3.2 23.8 1.0 OD1 A:ASN120 3.5 34.0 1.0 N A:CYS65 3.5 23.2 1.0 ND2 A:ASN120 3.5 25.6 1.0 CG A:ASN120 3.7 31.3 1.0 CA A:CYS65 3.8 23.5 1.0 O A:HOH406 3.9 26.5 1.0 O A:HOH439 4.0 42.0 1.0 OE2 A:GLU92 4.0 39.1 1.0 C A:ASP64 4.1 27.0 1.0 CG A:GLU92 4.1 37.5 1.0 CD A:GLU92 4.5 37.6 1.0 OG1 A:THR97 4.5 25.5 1.0 CB A:ASN120 4.6 32.8 1.0 CA A:ASP64 4.6 24.9 1.0 O A:ASP64 4.7 25.4 1.0 O A:HOH456 4.9 37.5 1.0 CD1 A:LEU74 4.9 33.9 1.0 CG A:LEU74 5.0 34.0 1.0

Arsenic binding site 2 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As400 b:41.7 occ:1.00 AS A:CAC400 0.0 41.7 1.0 O1 A:CAC400 1.3 17.1 1.0 C2 A:CAC400 2.1 38.0 1.0 C1 A:CAC400 2.2 38.8 1.0 SG A:CYS130 2.2 24.7 1.0 CB A:CYS130 3.2 25.2 1.0 O A:HOH507 4.2 56.3 1.0 CG1 A:VAL126 4.4 23.6 1.0 CD2 A:PHE121 4.5 32.1 1.0 CG A:PHE121 4.5 30.2 1.0 CA A:CYS130 4.6 22.7 1.0 CB A:PHE121 4.7 27.6 1.0 CG2 A:ILE135 4.7 23.5 1.0 O A:VAL126 4.8 23.1 1.0 CD1 A:LEU101 4.8 28.1 1.0 CD1 A:PHE121 4.8 28.4 1.0 CE2 A:PHE121 4.9 33.1 1.0 O A:ILE135 4.9 24.1 1.0

J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe. The Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity. Biochemistry V. 38 8892 1999.
ISSN: ISSN 0006-2960
PubMed: 10413462
DOI: 10.1021/BI9907173