Arsenic in PDB 1b9f: Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

All present enzymatic activity of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity:
2.7.7.49;

The structure of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9f was solved by J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.00 / 1.70
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	72.440, 72.440, 65.420, 90.00, 90.00, 120.00
R / Rfree (%)	24.3 / 28

The binding sites of Arsenic atom in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity (pdb code 1b9f). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity, PDB code: 1b9f:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As300 b:33.6 occ:1.00 AS A:CAC300 0.0 33.6 1.0 O1 A:CAC300 1.3 43.0 1.0 C1 A:CAC300 2.2 36.2 1.0 SG A:CYS65 2.3 27.1 1.0 C2 A:CAC300 2.3 35.3 1.0 CB A:CYS65 3.2 26.7 1.0 OD1 A:ASN120 3.4 32.4 1.0 N A:CYS65 3.5 24.8 1.0 ND2 A:ASN120 3.5 29.4 1.0 CG A:ASN120 3.6 31.7 1.0 O A:HOH406 3.8 28.1 1.0 CA A:CYS65 3.8 24.7 1.0 O A:HOH433 4.0 44.9 1.0 C A:ASP64 4.0 26.7 1.0 OE2 A:GLU92 4.2 40.9 1.0 CG A:GLU92 4.3 41.1 1.0 OG1 A:THR97 4.5 25.9 1.0 CA A:ASP64 4.6 26.9 1.0 CB A:ASN120 4.7 31.8 1.0 O A:ASP64 4.7 25.8 1.0 CD A:GLU92 4.8 42.5 1.0 O A:HOH416 4.8 35.9 1.0

Arsenic binding site 2 out of 2 in the Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity within 5.0Å range: probe atom residue distance (Å) B Occ A:As400 b:37.4 occ:1.00 AS A:CAC400 0.0 37.4 1.0 O1 A:CAC400 1.3 38.6 1.0 C1 A:CAC400 2.2 36.9 1.0 C2 A:CAC400 2.3 36.7 1.0 SG A:CYS130 2.3 23.4 1.0 CB A:CYS130 3.0 24.9 1.0 CG2 A:ILE135 4.1 24.2 1.0 O A:ILE135 4.2 23.9 1.0 N A:GLN137 4.2 33.0 1.0 CB A:GLN137 4.3 38.4 1.0 C A:LYS136 4.3 30.8 1.0 CA A:CYS130 4.4 22.3 1.0 CA A:GLN137 4.5 35.7 1.0 O A:LYS136 4.5 29.5 1.0 C A:ILE135 4.6 23.9 1.0 CB A:ILE135 4.7 25.7 1.0 O A:HOH465 4.7 47.1 1.0 CA A:LYS136 4.7 31.4 1.0 N A:LYS136 4.8 26.4 1.0 O A:HOH452 4.9 40.1 1.0

J.Greenwald, V.Le, S.L.Butler, F.D.Bushman, S.Choe. The Mobility of An Hiv-1 Integrase Active Site Loop Is Correlated with Catalytic Activity. Biochemistry V. 38 8892 1999.
ISSN: ISSN 0006-2960
PubMed: 10413462
DOI: 10.1021/BI9907173