Atomistry » Arsenic » PDB 1b92-1fyx » 1bhl
Atomistry »
  Arsenic »
    PDB 1b92-1fyx »
      1bhl »

Arsenic in PDB 1bhl: Cacodylated Catalytic Domain of Hiv-1 Integrase

Enzymatic activity of Cacodylated Catalytic Domain of Hiv-1 Integrase

All present enzymatic activity of Cacodylated Catalytic Domain of Hiv-1 Integrase:
2.7.7.49;

Protein crystallography data

The structure of Cacodylated Catalytic Domain of Hiv-1 Integrase, PDB code: 1bhl was solved by S.Maignan, J.P.Guilloteau, Q.Zhou-Liu, C.Clement-Mella, V.Mikol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 15.00 / 2.20
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 72.500, 72.500, 65.800, 90.00, 90.00, 120.00
R / Rfree (%) 22.4 / 26.4

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Cacodylated Catalytic Domain of Hiv-1 Integrase (pdb code 1bhl). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Cacodylated Catalytic Domain of Hiv-1 Integrase, PDB code: 1bhl:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1bhl

Go back to Arsenic Binding Sites List in 1bhl
Arsenic binding site 1 out of 2 in the Cacodylated Catalytic Domain of Hiv-1 Integrase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Cacodylated Catalytic Domain of Hiv-1 Integrase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As65

b:33.8
occ:1.00
AS A:CAS65 0.0 33.8 1.0
CE1 A:CAS65 1.9 30.9 1.0
CE2 A:CAS65 1.9 29.2 1.0
SG A:CAS65 2.2 29.1 1.0
CB A:CAS65 3.0 29.3 1.0
OD1 A:ASN120 3.5 30.1 1.0
ND2 A:ASN120 3.5 25.7 1.0
N A:CAS65 3.6 27.9 1.0
CG A:ASN120 3.6 30.4 1.0
CG A:GLU92 3.8 42.3 1.0
CA A:CAS65 3.9 30.2 1.0
OE2 A:GLU92 4.0 49.4 1.0
O A:HOH221 4.1 32.0 1.0
C A:ASP64 4.2 27.0 1.0
CD1 A:LEU74 4.2 36.9 1.0
CD A:GLU92 4.2 44.3 1.0
OG1 A:THR97 4.5 27.0 1.0
O A:HOH238 4.6 43.3 1.0
CA A:ASP64 4.7 26.3 1.0
CB A:ASN120 4.7 28.5 1.0
O A:HOH230 4.8 44.8 1.0
O A:ASP64 4.8 26.5 1.0
O A:HOH208 4.9 25.0 1.0

Arsenic binding site 2 out of 2 in 1bhl

Go back to Arsenic Binding Sites List in 1bhl
Arsenic binding site 2 out of 2 in the Cacodylated Catalytic Domain of Hiv-1 Integrase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Cacodylated Catalytic Domain of Hiv-1 Integrase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As130

b:37.3
occ:1.00
AS A:CAS130 0.0 37.3 1.0
CE1 A:CAS130 1.7 29.2 1.0
CE2 A:CAS130 1.8 27.2 1.0
SG A:CAS130 2.3 28.1 1.0
CB A:CAS130 3.2 23.8 1.0
CG2 A:ILE135 4.2 27.7 1.0
O A:ILE135 4.2 29.8 1.0
N A:GLN137 4.3 38.3 1.0
C A:LYS136 4.4 35.4 1.0
O A:LYS136 4.5 31.4 1.0
CA A:GLN137 4.5 42.5 1.0
CA A:CAS130 4.6 22.6 1.0
C A:ILE135 4.6 31.7 1.0
CB A:GLN137 4.7 44.9 1.0
CB A:ILE135 4.7 28.1 1.0
CD2 A:PHE121 4.8 22.2 1.0
NE2 A:GLN137 4.9 47.7 1.0
CA A:LYS136 4.9 35.5 1.0
CG1 A:VAL126 4.9 21.4 1.0
CG A:GLN137 5.0 46.7 1.0
N A:LYS136 5.0 33.1 1.0

Reference:

S.Maignan, J.P.Guilloteau, Q.Zhou-Liu, C.Clement-Mella, V.Mikol. Crystal Structures of the Catalytic Domain of Hiv-1 Integrase Free and Complexed with Its Metal Cofactor: High Level of Similarity of the Active Site with Other Viral Integrases. J.Mol.Biol. V. 282 359 1998.
ISSN: ISSN 0022-2836
PubMed: 9735293
DOI: 10.1006/JMBI.1998.2002
Page generated: Sun Jul 6 22:50:21 2025

Last articles

As in 6QHK
As in 6RCQ
As in 6QA0
As in 6N6Q
As in 6QM3
As in 6PI4
As in 6NNA
As in 6NSE
As in 6NUJ
As in 6LMI
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy