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Arsenic in PDB 1foo: Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free)

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free)

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free):
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free), PDB code: 1foo was solved by C.S.Raman, H.Li, P.Martasek, B.S.S.Masters, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.52 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.206, 106.555, 156.671, 90.00, 90.00, 90.00
R / Rfree (%) 22.3 / 25.3

Other elements in 1foo:

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free) also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free) (pdb code 1foo). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free), PDB code: 1foo:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1foo

Go back to Arsenic Binding Sites List in 1foo
Arsenic binding site 1 out of 2 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As1950

b:52.8
occ:1.00
AS A:CAC1950 0.0 52.8 1.0
C1 A:CAC1950 1.8 47.9 1.0
C2 A:CAC1950 1.8 48.0 1.0
SG A:CYS384 2.3 42.4 1.0
CB A:CYS384 3.3 37.7 1.0
CA A:CYS384 3.9 36.1 1.0
CE3 A:TRP324 4.4 35.9 1.0
CD1 A:LEU328 4.6 34.1 1.0
CD2 A:TRP324 4.6 35.9 1.0
N A:CYS384 4.8 34.7 1.0
CG A:TRP324 4.9 35.5 1.0
CB A:TRP324 4.9 35.8 1.0
CZ3 A:TRP324 5.0 35.8 1.0

Arsenic binding site 2 out of 2 in 1foo

Go back to Arsenic Binding Sites List in 1foo
Arsenic binding site 2 out of 2 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Free) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As2950

b:55.9
occ:1.00
AS B:CAC2950 0.0 55.9 1.0
C1 B:CAC2950 1.8 54.1 1.0
C2 B:CAC2950 1.8 53.5 1.0
SG B:CYS384 2.3 50.5 1.0
CB B:CYS384 3.1 47.7 1.0
CA B:CYS384 3.7 47.0 1.0
CE3 B:TRP324 4.5 49.8 1.0
N B:CYS384 4.7 46.5 1.0
CB B:TRP324 4.8 49.0 1.0
CD2 B:TRP324 4.8 49.9 1.0
C B:CYS384 4.9 47.0 1.0
CG B:TRP324 4.9 49.7 1.0
O B:CYS384 4.9 46.6 1.0

Reference:

H.Li, C.S.Raman, P.Martasek, B.S.Masters, T.L.Poulos. Crystallographic Studies on Endothelial Nitric Oxide Synthase Complexed with Nitric Oxide and Mechanism-Based Inhibitors. Biochemistry V. 40 5399 2001.
ISSN: ISSN 0006-2960
PubMed: 11331003
DOI: 10.1021/BI002658V
Page generated: Sun Jul 6 22:53:51 2025

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