Atomistry » Arsenic » PDB 1b92-1fyx » 1fop
Atomistry »
  Arsenic »
    PDB 1b92-1fyx »
      1fop »

Arsenic in PDB 1fop: Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound)

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound)

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound):
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound), PDB code: 1fop was solved by C.S.Raman, H.Li, P.Martasek, B.S.S.Masters, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.19 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.549, 106.247, 156.743, 90.00, 90.00, 90.00
R / Rfree (%) 22 / 27.7

Other elements in 1fop:

The structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound) also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound) (pdb code 1fop). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound), PDB code: 1fop:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1fop

Go back to Arsenic Binding Sites List in 1fop
Arsenic binding site 1 out of 2 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As1950

b:70.2
occ:1.00
AS A:CAC1950 0.0 70.2 1.0
C2 A:CAC1950 1.8 65.8 1.0
C1 A:CAC1950 1.8 65.3 1.0
SG A:CYS384 2.3 60.3 1.0
CB A:CYS384 3.3 51.7 1.0
CA A:CYS384 4.1 49.7 1.0
CE3 A:TRP324 4.4 44.8 1.0
CD1 A:LEU328 4.5 38.4 1.0
CD2 A:TRP324 4.6 45.0 1.0
CB A:TRP324 4.7 45.3 1.0
CG A:TRP324 4.8 44.9 1.0
N A:CYS384 4.9 48.0 1.0
CZ3 A:TRP324 5.0 45.1 1.0

Arsenic binding site 2 out of 2 in 1fop

Go back to Arsenic Binding Sites List in 1fop
Arsenic binding site 2 out of 2 in the Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Bovine Endothelial Nitric Oxide Synthase Heme Domain Complexed with L- Arg and No(H4B-Bound) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As2950

b:84.6
occ:1.00
AS B:CAC2950 0.0 84.6 1.0
C1 B:CAC2950 1.8 82.2 1.0
C2 B:CAC2950 1.8 81.3 1.0
SG B:CYS384 2.3 76.0 1.0
CB B:CYS384 3.1 68.3 1.0
CA B:CYS384 3.7 66.4 1.0
CE3 B:TRP324 4.4 68.8 1.0
CD2 B:TRP324 4.6 68.9 1.0
N B:CYS384 4.7 64.8 1.0
CG B:TRP324 4.7 68.7 1.0
CB B:TRP324 4.7 68.1 1.0
C B:CYS384 4.8 65.8 1.0
O B:CYS384 4.8 65.9 1.0
CD2 B:LEU328 4.9 62.0 1.0

Reference:

H.Li, C.S.Raman, P.Martasek, B.S.Masters, T.L.Poulos. Crystallographic Studies on Endothelial Nitric Oxide Synthase Complexed with Nitric Oxide and Mechanism-Based Inhibitors. Biochemistry V. 40 5399 2001.
ISSN: ISSN 0006-2960
PubMed: 11331003
DOI: 10.1021/BI002658V
Page generated: Sat Dec 12 01:36:28 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy