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Arsenic in PDB 1nse: Bovine Endothelial Nitric Oxide Synthase

Enzymatic activity of Bovine Endothelial Nitric Oxide Synthase

All present enzymatic activity of Bovine Endothelial Nitric Oxide Synthase:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nitric Oxide Synthase, PDB code: 1nse was solved by C.S.Raman, H.Li, P.Martasek, V.Kral, B.S.S.Masters, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.90
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 58.000, 106.550, 156.220, 90.00, 90.00, 90.00
R / Rfree (%) 20.6 / 27.8

Other elements in 1nse:

The structure of Bovine Endothelial Nitric Oxide Synthase also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Bovine Endothelial Nitric Oxide Synthase (pdb code 1nse). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Bovine Endothelial Nitric Oxide Synthase, PDB code: 1nse:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1nse

Go back to Arsenic Binding Sites List in 1nse
Arsenic binding site 1 out of 2 in the Bovine Endothelial Nitric Oxide Synthase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Bovine Endothelial Nitric Oxide Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As950

b:66.5
occ:1.00
AS A:CAC950 0.0 66.5 1.0
C2 A:CAC950 1.8 46.2 1.0
C1 A:CAC950 1.8 59.4 1.0
SG A:CYS384 2.5 33.4 1.0
CB A:CYS384 3.3 22.9 1.0
CA A:CYS384 3.9 20.8 1.0
CE3 A:TRP324 4.5 20.6 1.0
N A:CYS384 4.6 27.7 1.0
CD2 A:TRP324 4.7 23.2 1.0
CD1 A:LEU328 4.9 25.4 1.0
CB A:TRP324 4.9 25.1 1.0
CG A:TRP324 4.9 28.4 1.0

Arsenic binding site 2 out of 2 in 1nse

Go back to Arsenic Binding Sites List in 1nse
Arsenic binding site 2 out of 2 in the Bovine Endothelial Nitric Oxide Synthase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Bovine Endothelial Nitric Oxide Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As950

b:73.4
occ:1.00
AS B:CAC950 0.0 73.4 1.0
C2 B:CAC950 1.8 75.2 1.0
C1 B:CAC950 1.8 78.0 1.0
SG B:CYS384 2.1 47.9 1.0
CB B:CYS384 3.1 35.8 1.0
CA B:CYS384 3.4 33.5 1.0
CE3 B:TRP324 4.4 42.0 1.0
N B:CYS384 4.4 37.8 1.0
C B:CYS384 4.5 31.6 1.0
O B:CYS384 4.5 39.2 1.0
CD2 B:TRP324 4.6 41.1 1.0
CB B:TRP324 4.8 32.3 1.0
O B:HOH1011 4.8 53.4 1.0
CG B:TRP324 4.8 35.3 1.0
O B:HOH1141 4.8 66.8 1.0
CZ3 B:TRP324 5.0 37.3 1.0

Reference:

C.S.Raman, H.Li, P.Martasek, V.Kral, B.S.Masters, T.L.Poulos. Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase: A Paradigm For Pterin Function Involving A Novel Metal Center. Cell(Cambridge,Mass.) V. 95 939 1998.
ISSN: ISSN 0092-8674
PubMed: 9875848
DOI: 10.1016/S0092-8674(00)81718-3
Page generated: Tue Oct 27 16:46:56 2020

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