Atomistry » Arsenic » PDB 1glj-1pqu » 1p6n
Atomistry »
  Arsenic »
    PDB 1glj-1pqu »
      1p6n »

Arsenic in PDB 1p6n: Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound

Enzymatic activity of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound

All present enzymatic activity of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound, PDB code: 1p6n was solved by M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.-M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 42.55 / 2.50
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.669, 106.292, 156.524, 90.00, 90.00, 90.00
R / Rfree (%) 21.8 / 27.8

Other elements in 1p6n:

The structure of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound (pdb code 1p6n). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound, PDB code: 1p6n:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1p6n

Go back to Arsenic Binding Sites List in 1p6n
Arsenic binding site 1 out of 2 in the Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As850

b:83.8
occ:1.00
AS A:CAC850 0.0 83.8 1.0
C1 A:CAC850 1.8 83.3 1.0
C2 A:CAC850 1.8 84.5 1.0
SG A:CYS384 2.9 60.1 1.0
CB A:CYS384 3.2 52.9 1.0
CA A:CYS384 3.9 48.7 1.0
CE3 A:TRP324 3.9 57.1 1.0
CD2 A:TRP324 4.2 56.4 1.0
CB A:TRP324 4.4 48.4 1.0
CG A:TRP324 4.5 52.1 1.0
CZ3 A:TRP324 4.5 55.6 1.0
C A:CYS384 4.9 49.7 1.0
O A:CYS384 4.9 48.5 1.0
N A:CYS384 4.9 45.7 1.0

Arsenic binding site 2 out of 2 in 1p6n

Go back to Arsenic Binding Sites List in 1p6n
Arsenic binding site 2 out of 2 in the Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Bovine Endothelial Nos Heme Domain with L-N(Omega)-Nitroarginine-(4R)- Amino-L-Proline Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As852

b:97.0
occ:1.00
AS B:CAC852 0.0 97.0 1.0
C1 B:CAC852 1.8 92.2 1.0
C2 B:CAC852 1.8 96.2 1.0
SG B:CYS384 3.0 72.7 1.0
CB B:CYS384 3.3 67.1 1.0
CA B:CYS384 3.9 65.9 1.0
CE3 B:TRP324 4.0 82.7 1.0
CZ3 B:TRP324 4.5 81.8 1.0
CD2 B:TRP324 4.5 82.9 1.0
CB B:TRP324 4.8 75.8 1.0
N B:CYS384 4.8 64.0 1.0
C B:CYS384 4.9 66.5 1.0
CG B:TRP324 4.9 80.8 1.0
O B:CYS384 4.9 67.5 1.0

Reference:

M.L.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, J.M.Hah, J.A.Gomez-Vidal, E.A.Litzinger, R.B.Silverman, T.L.Poulos. Structural Basis For Dipeptide Amide Isoform-Selective Inhibition of Neuronal Nitric Oxide Synthase. Nat.Struct.Mol.Biol. V. 11 54 2004.
ISSN: ISSN 1545-9993
PubMed: 14718923
DOI: 10.1038/NSMB704
Page generated: Tue Oct 27 16:47:03 2020

Last articles

Xe in 6AYK
Xe in 6QII
Xe in 6ASM
Xe in 5NSW
Xe in 6FY9
Xe in 5O1K
Xe in 5O27
Xe in 5M69
Xe in 5KPU
Xe in 5I63
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy