Atomistry » Arsenic » PDB 1q2o-1yhc » 1rs8
Atomistry »
  Arsenic »
    PDB 1q2o-1yhc »
      1rs8 »

Arsenic in PDB 1rs8: Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound

Enzymatic activity of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound

All present enzymatic activity of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound:
1.14.13.39;

Protein crystallography data

The structure of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound, PDB code: 1rs8 was solved by M.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, R.B.Silverman, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.83 / 2.30
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.009, 106.215, 156.536, 90.00, 90.00, 90.00
R / Rfree (%) 22.2 / 27.6

Other elements in 1rs8:

The structure of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound (pdb code 1rs8). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound, PDB code: 1rs8:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1rs8

Go back to Arsenic Binding Sites List in 1rs8
Arsenic binding site 1 out of 2 in the Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As850

b:77.4
occ:1.00
AS A:CAC850 0.0 77.4 1.0
C1 A:CAC850 1.8 76.3 1.0
C2 A:CAC850 1.8 78.3 1.0
SG A:CYS384 2.8 59.2 1.0
CB A:CYS384 3.2 53.3 1.0
CA A:CYS384 3.9 50.8 1.0
CE3 A:TRP324 4.0 48.6 1.0
CD2 A:TRP324 4.2 51.8 1.0
CG A:TRP324 4.5 51.0 1.0
CB A:TRP324 4.5 50.0 1.0
CZ3 A:TRP324 4.6 48.7 1.0
CD1 A:LEU328 4.8 40.1 1.0
C A:CYS384 4.9 49.3 1.0
O A:CYS384 4.9 47.9 1.0
N A:CYS384 4.9 50.3 1.0

Arsenic binding site 2 out of 2 in 1rs8

Go back to Arsenic Binding Sites List in 1rs8
Arsenic binding site 2 out of 2 in the Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Bovine Endothelial Nos Heme Domain with D-Lysine-D-Nitroarginine Amide Bound within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As852

b:86.5
occ:1.00
AS B:CAC852 0.0 86.5 1.0
C1 B:CAC852 1.8 89.3 1.0
C2 B:CAC852 1.8 88.3 1.0
SG B:CYS384 3.0 77.2 1.0
CB B:CYS384 3.4 71.3 1.0
CA B:CYS384 3.9 69.0 1.0
O B:HOH988 4.4 60.4 1.0
CE3 B:TRP324 4.4 75.0 1.0
CD2 B:TRP324 4.7 76.7 1.0
CD2 B:LEU328 4.7 66.5 1.0
CZ3 B:TRP324 4.8 71.9 1.0
N B:CYS384 4.9 68.1 1.0
C B:CYS384 5.0 68.8 1.0

Reference:

M.Flinspach, H.Li, J.Jamal, W.Yang, H.Huang, R.B.Silverman, T.L.Poulos. Structures of the Neuronal and Endothelial Nitric Oxide Synthase Heme Domain with D-Nitroarginine-Containing Dipeptide Inhibitors Bound. Biochemistry V. 43 5181 2004.
ISSN: ISSN 0006-2960
PubMed: 15122883
DOI: 10.1021/BI0361867
Page generated: Sat Dec 12 01:37:16 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy