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Arsenic in PDB 1ta4: Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate

Enzymatic activity of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate

All present enzymatic activity of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate:
1.2.1.11;

Protein crystallography data

The structure of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate, PDB code: 1ta4 was solved by R.E.Viola, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.28
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 113.769, 54.843, 57.487, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 28.6

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate (pdb code 1ta4). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate, PDB code: 1ta4:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 1ta4

Go back to Arsenic Binding Sites List in 1ta4
Arsenic binding site 1 out of 2 in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As373

b:60.9
occ:1.00
AS A:ART373 0.0 60.9 1.0
O1 A:ART373 1.7 61.3 1.0
O2 A:ART373 1.7 60.1 1.0
O3 A:ART373 1.7 60.6 1.0
O4 A:ART373 1.7 62.1 1.0
NH2 A:ARG102 3.6 29.0 1.0
NH1 A:ARG102 3.8 27.1 1.0
NZ A:LYS244 4.0 43.4 1.0
O A:HOH431 4.0 22.2 1.0
CZ A:ARG102 4.2 28.3 1.0
OD1 A:ASN134 4.2 31.4 1.0
O A:HOH401 4.4 37.4 1.0
CA A:ASN134 4.6 30.8 1.0
O3 A:ART374 4.6 77.1 1.0
O1 A:ART374 4.7 79.3 1.0
SG A:CYS135 4.8 35.0 1.0
N A:CYS135 4.9 30.0 1.0
CB A:SER99 5.0 34.6 1.0
CB A:ASN134 5.0 30.8 1.0

Arsenic binding site 2 out of 2 in 1ta4

Go back to Arsenic Binding Sites List in 1ta4
Arsenic binding site 2 out of 2 in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As374

b:79.1
occ:1.00
AS A:ART374 0.0 79.1 1.0
O1 A:ART374 1.7 79.3 1.0
O2 A:ART374 1.7 78.3 1.0
O3 A:ART374 1.7 77.1 1.0
O4 A:ART374 1.7 79.1 1.0
OG A:SER99 3.6 33.5 1.0
CE A:LYS240 3.8 41.6 1.0
NZ A:LYS244 3.9 43.4 1.0
O2 A:ART373 3.9 60.1 1.0
OD2 A:ASP231 4.1 33.9 1.0
CD A:LYS240 4.3 39.3 1.0
O A:HOH401 4.5 37.4 1.0
O A:HOH426 4.5 42.5 1.0
OD1 A:ASP231 4.6 33.8 1.0
CB A:SER99 4.7 34.6 1.0
CG A:ASP231 4.8 36.0 1.0
CE A:LYS244 4.9 41.5 1.0

Reference:

C.R.Faehnle, J.Blanco, R.E.Viola. Structural Basis For Discrimination Between Oxyanion Substrates or Inhibitors in Aspartate-Beta-Semialdehyde Dehydrogenase. Acta Crystallogr.,Sect.D V. 60 2320 2004.
ISSN: ISSN 0907-4449
PubMed: 15583380
DOI: 10.1107/S0907444904026411
Page generated: Tue Oct 27 16:47:26 2020

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