Arsenic in PDB 1ta4: Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate

All present enzymatic activity of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate:
1.2.1.11;

The structure of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate, PDB code: 1ta4 was solved by R.E.Viola, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.28
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	113.769, 54.843, 57.487, 90.00, 90.00, 90.00
R / Rfree (%)	22.5 / 28.6

The binding sites of Arsenic atom in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate (pdb code 1ta4). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate, PDB code: 1ta4:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate within 5.0Å range: probe atom residue distance (Å) B Occ A:As373 b:60.9 occ:1.00 AS A:ART373 0.0 60.9 1.0 O1 A:ART373 1.7 61.3 1.0 O2 A:ART373 1.7 60.1 1.0 O3 A:ART373 1.7 60.6 1.0 O4 A:ART373 1.7 62.1 1.0 NH2 A:ARG102 3.6 29.0 1.0 NH1 A:ARG102 3.8 27.1 1.0 NZ A:LYS244 4.0 43.4 1.0 O A:HOH431 4.0 22.2 1.0 CZ A:ARG102 4.2 28.3 1.0 OD1 A:ASN134 4.2 31.4 1.0 O A:HOH401 4.4 37.4 1.0 CA A:ASN134 4.6 30.8 1.0 O3 A:ART374 4.6 77.1 1.0 O1 A:ART374 4.7 79.3 1.0 SG A:CYS135 4.8 35.0 1.0 N A:CYS135 4.9 30.0 1.0 CB A:SER99 5.0 34.6 1.0 CB A:ASN134 5.0 30.8 1.0

Arsenic binding site 2 out of 2 in the Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Aspartate-Semialdehyde Dehydrogenase From Haemophilus Influenzae with A Bound Arsenate within 5.0Å range: probe atom residue distance (Å) B Occ A:As374 b:79.1 occ:1.00 AS A:ART374 0.0 79.1 1.0 O1 A:ART374 1.7 79.3 1.0 O2 A:ART374 1.7 78.3 1.0 O3 A:ART374 1.7 77.1 1.0 O4 A:ART374 1.7 79.1 1.0 OG A:SER99 3.6 33.5 1.0 CE A:LYS240 3.8 41.6 1.0 NZ A:LYS244 3.9 43.4 1.0 O2 A:ART373 3.9 60.1 1.0 OD2 A:ASP231 4.1 33.9 1.0 CD A:LYS240 4.3 39.3 1.0 O A:HOH401 4.5 37.4 1.0 O A:HOH426 4.5 42.5 1.0 OD1 A:ASP231 4.6 33.8 1.0 CB A:SER99 4.7 34.6 1.0 CG A:ASP231 4.8 36.0 1.0 CE A:LYS244 4.9 41.5 1.0

C.R.Faehnle, J.Blanco, R.E.Viola. Structural Basis For Discrimination Between Oxyanion Substrates or Inhibitors in Aspartate-Beta-Semialdehyde Dehydrogenase. Acta Crystallogr.,Sect.D V. 60 2320 2004.
ISSN: ISSN 0907-4449
PubMed: 15583380
DOI: 10.1107/S0907444904026411