Arsenic in PDB 1tad: Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Protein crystallography data
The structure of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-, PDB code: 1tad
was solved by
J.Sondek,
D.G.Lambright,
J.P.Noel,
H.E.Hamm,
P.B.Sigler,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
8.00 /
1.70
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
74.900,
108.200,
79.000,
90.00,
111.70,
90.00
|
R / Rfree (%)
|
20.9 /
26.6
|
Other elements in 1tad:
The structure of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- also contains other interesting chemical elements:
Arsenic Binding Sites:
The binding sites of Arsenic atom in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
(pdb code 1tad). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total 6 binding sites of Arsenic where determined in the
Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-, PDB code: 1tad:
Jump to Arsenic binding site number:
1;
2;
3;
4;
5;
6;
Arsenic binding site 1 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 1 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 1 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:As353
b:29.0
occ:1.00
|
AS
|
A:CAC353
|
0.0
|
29.0
|
1.0
|
C2
|
A:CAC353
|
1.7
|
30.9
|
1.0
|
O1
|
A:CAC353
|
1.8
|
30.6
|
1.0
|
C1
|
A:CAC353
|
1.8
|
25.5
|
1.0
|
SG
|
A:CYS62
|
2.2
|
20.9
|
1.0
|
CB
|
A:CYS62
|
3.1
|
17.2
|
1.0
|
O
|
A:PRO165
|
3.6
|
12.4
|
1.0
|
O
|
A:HOH701
|
4.0
|
26.5
|
1.0
|
O
|
A:HOH460
|
4.2
|
30.2
|
1.0
|
CD1
|
B:ILE180
|
4.2
|
14.2
|
1.0
|
O
|
A:SER58
|
4.4
|
12.7
|
1.0
|
CA
|
A:CYS62
|
4.5
|
16.1
|
1.0
|
CG1
|
A:VAL164
|
4.7
|
11.2
|
1.0
|
CA
|
A:LEU59
|
4.7
|
13.1
|
1.0
|
C
|
A:PRO165
|
4.8
|
10.2
|
1.0
|
C
|
A:SER58
|
5.0
|
11.5
|
1.0
|
O
|
A:TYR57
|
5.0
|
14.3
|
1.0
|
|
Arsenic binding site 2 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 2 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 2 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:As354
b:35.8
occ:1.00
|
AS
|
A:CAC354
|
0.0
|
35.8
|
1.0
|
C1
|
A:CAC354
|
1.8
|
36.9
|
1.0
|
O1
|
A:CAC354
|
1.8
|
35.3
|
1.0
|
C2
|
A:CAC354
|
1.8
|
31.6
|
1.0
|
SG
|
A:CYS210
|
2.2
|
23.1
|
1.0
|
CB
|
A:CYS210
|
3.1
|
17.8
|
1.0
|
CB
|
A:VAL197
|
3.8
|
16.6
|
1.0
|
CG1
|
A:VAL197
|
3.9
|
16.0
|
1.0
|
CD1
|
A:ILE180
|
4.1
|
17.5
|
1.0
|
CG1
|
A:ILE180
|
4.1
|
16.5
|
1.0
|
CG2
|
A:VAL197
|
4.2
|
17.2
|
1.0
|
O
|
A:TRP207
|
4.3
|
14.4
|
1.0
|
CA
|
A:TRP207
|
4.3
|
15.9
|
1.0
|
CA
|
A:CYS210
|
4.5
|
16.2
|
1.0
|
CG2
|
A:ILE180
|
4.6
|
13.8
|
1.0
|
CD1
|
A:TRP207
|
4.7
|
14.3
|
1.0
|
C
|
A:TRP207
|
4.8
|
15.4
|
1.0
|
N
|
A:CYS210
|
4.8
|
14.4
|
1.0
|
CG
|
A:TRP207
|
5.0
|
13.9
|
1.0
|
|
Arsenic binding site 3 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 3 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 3 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:As353
b:31.9
occ:1.00
|
AS
|
B:CAC353
|
0.0
|
31.9
|
1.0
|
C1
|
B:CAC353
|
1.7
|
33.8
|
1.0
|
O1
|
B:CAC353
|
1.8
|
32.4
|
1.0
|
C2
|
B:CAC353
|
1.9
|
28.6
|
1.0
|
SG
|
B:CYS62
|
2.2
|
21.1
|
1.0
|
CB
|
B:CYS62
|
3.0
|
17.0
|
1.0
|
O
|
B:PRO165
|
3.6
|
16.2
|
1.0
|
O
|
B:HOH528
|
3.7
|
24.8
|
1.0
|
O
|
B:HOH996
|
4.4
|
34.8
|
1.0
|
CA
|
B:CYS62
|
4.5
|
14.2
|
1.0
|
O
|
B:SER58
|
4.5
|
11.8
|
1.0
|
O
|
B:HOH850
|
4.7
|
20.4
|
1.0
|
CA
|
B:LEU59
|
4.7
|
11.4
|
1.0
|
CG1
|
B:VAL164
|
4.7
|
11.6
|
1.0
|
C
|
B:PRO165
|
4.7
|
15.0
|
1.0
|
C
|
B:SER58
|
4.9
|
12.6
|
1.0
|
O
|
B:TYR57
|
4.9
|
14.8
|
1.0
|
|
Arsenic binding site 4 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 4 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 4 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:As354
b:43.4
occ:1.00
|
AS
|
B:CAC354
|
0.0
|
43.4
|
1.0
|
C1
|
B:CAC354
|
1.8
|
43.6
|
1.0
|
O1
|
B:CAC354
|
1.8
|
43.0
|
1.0
|
C2
|
B:CAC354
|
1.8
|
42.6
|
1.0
|
SG
|
B:CYS210
|
2.2
|
32.9
|
1.0
|
CB
|
B:CYS210
|
2.9
|
24.9
|
1.0
|
CG1
|
B:VAL197
|
3.6
|
27.0
|
1.0
|
CG2
|
B:VAL197
|
3.7
|
20.4
|
1.0
|
O
|
B:TRP207
|
4.0
|
18.2
|
1.0
|
CA
|
B:TRP207
|
4.2
|
19.3
|
1.0
|
CB
|
B:VAL197
|
4.3
|
21.9
|
1.0
|
CG1
|
B:ILE180
|
4.3
|
14.7
|
1.0
|
CA
|
B:CYS210
|
4.3
|
21.6
|
1.0
|
CD1
|
B:ILE180
|
4.4
|
14.2
|
1.0
|
C
|
B:TRP207
|
4.5
|
18.9
|
1.0
|
N
|
B:CYS210
|
4.6
|
18.9
|
1.0
|
CD1
|
B:TRP207
|
4.6
|
15.6
|
1.0
|
CD1
|
B:LEU33
|
4.8
|
23.8
|
1.0
|
CG2
|
B:ILE180
|
4.8
|
12.1
|
1.0
|
CG
|
B:TRP207
|
4.8
|
19.2
|
1.0
|
CB
|
B:TRP207
|
4.8
|
19.3
|
1.0
|
O
|
B:LYS206
|
4.9
|
22.3
|
1.0
|
|
Arsenic binding site 5 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 5 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 5 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:As353
b:28.7
occ:1.00
|
AS
|
C:CAC353
|
0.0
|
28.7
|
1.0
|
O1
|
C:CAC353
|
1.8
|
36.8
|
1.0
|
C2
|
C:CAC353
|
1.9
|
24.5
|
1.0
|
C1
|
C:CAC353
|
1.9
|
25.1
|
1.0
|
SG
|
C:CYS62
|
2.2
|
19.0
|
1.0
|
CB
|
C:CYS62
|
3.1
|
13.4
|
1.0
|
O
|
C:PRO165
|
3.4
|
12.3
|
1.0
|
O
|
C:HOH904
|
3.7
|
32.0
|
1.0
|
O
|
C:HOH1392
|
4.1
|
38.7
|
1.0
|
CD1
|
A:ILE180
|
4.4
|
17.5
|
1.0
|
C
|
C:PRO165
|
4.6
|
11.5
|
1.0
|
CA
|
C:CYS62
|
4.6
|
13.6
|
1.0
|
CG1
|
C:VAL164
|
4.6
|
8.7
|
1.0
|
O
|
C:SER58
|
4.6
|
10.3
|
1.0
|
CA
|
C:LEU59
|
4.7
|
11.4
|
1.0
|
O
|
C:HOH953
|
5.0
|
24.6
|
1.0
|
|
Arsenic binding site 6 out
of 6 in 1tad
Go back to
Arsenic Binding Sites List in 1tad
Arsenic binding site 6 out
of 6 in the Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4-
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 6 of Gtpase Mechanism of Gproteins From the 1.7-Angstrom Crystal Structure of Transducin Alpha-Gdp-ALF4- within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:As354
b:48.9
occ:1.00
|
AS
|
C:CAC354
|
0.0
|
48.9
|
1.0
|
C1
|
C:CAC354
|
1.8
|
45.9
|
1.0
|
O1
|
C:CAC354
|
1.8
|
44.3
|
1.0
|
C2
|
C:CAC354
|
1.8
|
43.8
|
1.0
|
SG
|
C:CYS210
|
2.2
|
29.6
|
1.0
|
CB
|
C:CYS210
|
3.0
|
22.4
|
1.0
|
CB
|
C:VAL197
|
3.8
|
14.6
|
1.0
|
CG1
|
C:ILE180
|
3.9
|
16.8
|
1.0
|
CD1
|
C:ILE180
|
4.0
|
21.2
|
1.0
|
CG1
|
C:VAL197
|
4.1
|
11.6
|
1.0
|
O
|
C:TRP207
|
4.2
|
13.8
|
1.0
|
CG2
|
C:VAL197
|
4.3
|
17.8
|
1.0
|
CA
|
C:TRP207
|
4.4
|
15.5
|
1.0
|
CA
|
C:CYS210
|
4.4
|
17.6
|
1.0
|
CG2
|
C:ILE180
|
4.5
|
16.8
|
1.0
|
CD1
|
C:TRP207
|
4.7
|
14.5
|
1.0
|
N
|
C:CYS210
|
4.7
|
15.0
|
1.0
|
C
|
C:TRP207
|
4.8
|
14.6
|
1.0
|
CB
|
C:ILE180
|
4.9
|
16.9
|
1.0
|
CG
|
C:TRP207
|
5.0
|
15.4
|
1.0
|
|
Reference:
J.Sondek,
D.G.Lambright,
J.P.Noel,
H.E.Hamm,
P.B.Sigler.
Gtpase Mechanism of Gproteins From the 1.7-A Crystal Structure of Transducin Alpha-Gdp-Aif-4. Nature V. 372 276 1994.
ISSN: ISSN 0028-0836
PubMed: 7969474
DOI: 10.1038/372276A0
Page generated: Wed Jul 10 11:14:02 2024
|