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Arsenic in PDB 1xsl: Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap

Enzymatic activity of Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap

All present enzymatic activity of Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap:
2.7.7.7;

Protein crystallography data

The structure of Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap, PDB code: 1xsl was solved by M.Garcia-Diaz, K.Bebenek, J.M.Krahn, T.A.Kunkel, L.C.Pedersen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.47 / 2.30
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 191.504, 98.812, 104.519, 90.00, 90.00, 90.00
R / Rfree (%) 20.7 / 25.2

Other elements in 1xsl:

The structure of Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap also contains other interesting chemical elements:

Magnesium (Mg) 3 atoms
Sodium (Na) 6 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap (pdb code 1xsl). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap, PDB code: 1xsl:

Arsenic binding site 1 out of 1 in 1xsl

Go back to Arsenic Binding Sites List in 1xsl
Arsenic binding site 1 out of 1 in the Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Human Dna Polymerase Lambda in Complex with A One Nucleotide Dna Gap within 5.0Å range:
probe atom residue distance (Å) B Occ
D:As950

b:0.4
occ:0.50
 AS D:CAC950 0.0 0.4 0.5
O2 D:CAC950 1.6 0.3 0.5
O1 D:CAC950 1.6 0.1 0.5
C2 D:CAC950 1.8 0.3 0.5
C1 D:CAC950 2.0 0.2 0.5
O D:HOH688 4.1 43.3 1.0
O6 D:DG4 4.2 37.8 1.0
N7 D:DG4 4.3 36.3 1.0
O A:HOH1121 4.3 40.1 1.0
C6 D:DG4 4.9 37.5 1.0
C5 D:DG4 4.9 37.4 1.0

Reference:

M.Garcia-Diaz, K.Bebenek, J.M.Krahn, T.A.Kunkel, L.C.Pedersen. A Closed Conformation For the Pol Lambda Catalytic Cycle. Nat.Struct.Mol.Biol. V. 12 97 2005.
ISSN: ISSN 1545-9993
PubMed: 15608652
DOI: 10.1038/NSMB876
Page generated: Sun Jul 6 23:04:28 2025

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