Arsenic in PDB 2im1: Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

Enzymatic activity of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

All present enzymatic activity of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+, PDB code: 2im1 was solved by A.A.Thompson, O.B.Peersen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	28.20 / 2.50
*Space group*	P 6₅
*Cell size a, b, c (Å), α, β, γ (°)*	128.942, 128.942, 112.979, 90.00, 90.00, 120.00
*R / R_free (%)*	23.9 / 26.8

Other elements in 2im1:

The structure of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ also contains other interesting chemical elements:

Manganese	(Mn)	3 atoms
Sodium	(Na)	1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ (pdb code 2im1). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 4 binding sites of Arsenic where determined in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+, PDB code: 2im1:
Jump to Arsenic binding site number: 1; 2; 3; 4;

Arsenic binding site 1 out of 4 in 2im1

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Arsenic Binding Sites List in 2im1

Arsenic binding site 1 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As96 b:86.1 occ:1.00	AS	A:CAS96	0.0	86.1	1.0
	CE2	A:CAS96	2.2	84.1	1.0
	CE1	A:CAS96	2.3	84.6	1.0
	SG	A:CAS96	2.3	82.5	1.0
	CB	A:CAS96	3.1	78.3	1.0
	OD2	A:ASP99	4.0	72.5	1.0
	CA	A:CAS96	4.6	76.5	1.0
	CG	A:ASP99	4.6	72.5	1.0
	CB	A:GLU98	5.0	78.2	1.0

Arsenic binding site 2 out of 4 in 2im1

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Arsenic Binding Sites List in 2im1

Arsenic binding site 2 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As212 b:48.0 occ:1.00	AS	A:CAS212	0.0	48.0	1.0
	CE1	A:CAS212	2.2	48.5	1.0
	CE2	A:CAS212	2.2	43.5	1.0
	SG	A:CAS212	2.3	34.5	1.0
	CB	A:CAS212	3.3	32.5	1.0
	O	A:ALA209	3.4	27.0	1.0
	O	A:CAS212	3.5	29.7	1.0
	CD1	A:LEU374	3.7	38.9	1.0
	C	A:CAS212	3.9	27.3	1.0
	CA	A:CAS212	3.9	28.8	1.0
	N	A:CAS212	3.9	31.0	1.0
	C	A:ALA209	4.4	26.4	1.0
	CG	A:PRO214	4.4	25.5	1.0
	CD	A:PRO214	4.4	23.7	1.0
	CE2	A:TYR326	4.6	39.4	1.0
	CD2	A:TYR326	4.6	36.9	1.0
	CB	A:ALA209	4.7	22.8	1.0
	N	A:ASP213	4.8	24.8	1.0
	N	A:GLY211	4.9	33.2	1.0
	O	A:HOH519	5.0	35.8	1.0
	C	A:GLY211	5.0	32.1	1.0

Arsenic binding site 3 out of 4 in 2im1

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Arsenic Binding Sites List in 2im1

Arsenic binding site 3 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As281 b:48.5 occ:1.00	AS	A:CAS281	0.0	48.5	1.0
	CE2	A:CAS281	2.2	44.8	1.0
	CE1	A:CAS281	2.2	45.9	1.0
	SG	A:CAS281	2.2	41.3	1.0
	CB	A:CAS281	3.1	43.6	1.0
	O	A:SER271	3.9	43.6	1.0
	CA	A:CAS281	3.9	45.0	1.0
	C	A:SER271	4.1	45.1	1.0
	CA	A:HIS272	4.1	45.7	1.0
	CB	A:HIS272	4.2	44.3	1.0
	N	A:HIS272	4.2	44.8	1.0
	CZ2	A:TRP5	4.5	35.9	1.0
	CG	A:HIS272	4.5	43.2	1.0
	CD2	A:HIS272	4.7	42.2	1.0
	C	A:CAS281	4.8	43.8	1.0
	N	A:VAL282	4.9	41.2	1.0
	CA	A:SER271	4.9	45.6	1.0
	N	A:CAS281	5.0	47.0	1.0

Arsenic binding site 4 out of 4 in 2im1

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Arsenic Binding Sites List in 2im1

Arsenic binding site 4 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of Crystal Structure of Poliovirus Polymerase Complexed with Ctp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As290 b:70.7 occ:1.00	AS	A:CAS290	0.0	70.7	1.0
	CE2	A:CAS290	2.2	67.4	1.0
	CE1	A:CAS290	2.3	69.2	1.0
	SG	A:CAS290	2.3	63.7	1.0
	CB	A:CAS290	3.1	55.8	1.0
	SD	A:MET187	3.7	51.2	1.0
	CD2	A:LEU268	3.8	33.9	1.0
	CB	A:SER179	4.1	50.1	1.0
	CA	A:CAS290	4.2	52.8	1.0
	CD2	A:LEU154	4.6	43.2	1.0
	CG	A:LEU268	4.6	37.7	1.0
	OG	A:SER179	4.7	48.8	1.0
	CB	A:ASP183	4.8	57.5	1.0
	CD2	A:TYR267	4.9	62.2	1.0
	N	A:SER291	5.0	49.5	1.0
	CE	A:MET187	5.0	51.5	1.0

Reference:

A.A.Thompson, R.A.Albertini, O.B.Peersen. Stabilization of Poliovirus Polymerase By Ntp Binding and Fingers-Thumb Interactions. J.Mol.Biol. V. 366 1459 2007.
ISSN: ISSN 0022-2836
PubMed: 17223130
DOI: 10.1016/J.JMB.2006.11.070

Page generated: Sun Jul 6 23:11:02 2025

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