Arsenic in PDB 2iwr: Gtpase Like Domain of Centaurin Gamma 1 (Human)

The structure of Gtpase Like Domain of Centaurin Gamma 1 (Human), PDB code: 2iwr was solved by J.M.Elkins, M.Soundararajan, X.Yang, E.Papagrigoriou, M.Sundstrom, A.Edwards, C.Arrowsmith, J.Weigelt, D.A.Doyle, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.74 / 1.5
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	36.256, 62.146, 67.498, 90.00, 90.00, 90.00
R / Rfree (%)	15 / 21.4

The binding sites of Arsenic atom in the Gtpase Like Domain of Centaurin Gamma 1 (Human) (pdb code 2iwr). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Gtpase Like Domain of Centaurin Gamma 1 (Human), PDB code: 2iwr:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Gtpase Like Domain of Centaurin Gamma 1 (Human)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Gtpase Like Domain of Centaurin Gamma 1 (Human) within 5.0Å range: probe atom residue distance (Å) B Occ A:As200 b:42.7 occ:1.00 AS A:CAF200 0.0 42.7 1.0 O1 A:CAF200 1.9 46.1 1.0 CE1 A:CAF200 2.0 48.8 1.0 CE2 A:CAF200 2.0 39.0 1.0 SG A:CAF200 2.2 28.7 1.0 CB A:CAF200 3.0 26.5 1.0 O A:CYS206 4.0 31.3 1.0 O A:ARG197 4.1 28.3 1.0 N A:ALA201 4.1 28.9 1.0 CA A:CAF200 4.2 24.2 1.0 C A:CAF200 4.4 26.8 1.0 CB A:TYR208 4.5 22.2 1.0 O A:CAF200 4.6 27.8 1.0 N A:TYR208 4.6 21.7 1.0 CB A:ARG197 4.7 29.4 1.0 CA A:ARG197 4.7 27.1 1.0 CA A:ALA201 4.8 30.4 1.0 C A:CYS206 4.8 26.9 1.0 C A:ARG197 4.9 26.8 1.0 O A:HOH2184 4.9 40.5 1.0 O A:HOH2183 4.9 37.1 1.0 CA A:SER207 4.9 26.7 1.0 O A:HOH2190 4.9 33.2 1.0 C A:SER207 5.0 22.8 1.0

Arsenic binding site 2 out of 2 in the Gtpase Like Domain of Centaurin Gamma 1 (Human)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Gtpase Like Domain of Centaurin Gamma 1 (Human) within 5.0Å range: probe atom residue distance (Å) B Occ A:As212 b:31.2 occ:1.00 AS A:CAF212 0.0 31.2 1.0 CE2 A:CAF212 1.9 46.0 1.0 O1 A:CAF212 1.9 42.4 1.0 CE1 A:CAF212 2.0 34.6 1.0 SG A:CAF212 2.2 29.1 1.0 CB A:CAF212 3.0 26.3 1.0 O A:HOH2161 3.8 31.7 1.0 CA A:ASP181 3.9 25.1 1.0 O A:GLN180 3.9 24.1 1.0 CA A:CAF212 3.9 23.7 1.0 C A:GLN180 3.9 21.9 1.0 CB A:GLN180 3.9 21.9 1.0 OD1 A:ASP181 4.0 32.4 1.0 N A:ASP181 4.1 21.5 1.0 CG A:ASP181 4.2 26.7 1.0 OE1 A:GLN180 4.4 32.1 1.0 C A:CAF212 4.5 23.9 1.0 OG1 A:THR214 4.5 27.7 1.0 CA A:GLN180 4.6 22.5 1.0 CB A:ASP181 4.6 25.2 1.0 CB A:THR214 4.6 23.0 1.0 OD2 A:ASP181 4.6 26.4 1.0 O A:HOH2157 4.8 46.3 1.0 C A:ASP181 4.9 25.0 1.0 O A:ASP181 5.0 28.5 1.0

M.Soundararajan, X.Yang, J.M.Elkins, F.Sobott, D.A.Doyle. The Centaurin Gamma-1 Gtpase-Like Domain Functions As An Ntpase. Biochem.J. V. 401 679 2007.
ISSN: ISSN 0264-6021
PubMed: 17037982
DOI: 10.1042/BJ20060555