Arsenic in PDB 2iyo: Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition

Enzymatic activity of Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition

All present enzymatic activity of Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition:
1.1.1.44;

Protein crystallography data

The structure of Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition, PDB code: 2iyo was solved by R.Sundaramoorthy, J.Iulek, W.N.Hunter, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	19.83 / 2.40
*Space group*	P 3₂ 1 2
*Cell size a, b, c (Å), α, β, γ (°)*	60.582, 60.582, 243.128, 90.00, 90.00, 120.00
*R / R_free (%)*	15.9 / 22.1

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition (pdb code 2iyo). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition, PDB code: 2iyo:

Arsenic binding site 1 out of 1 in 2iyo

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Arsenic Binding Sites List in 2iyo

Arsenic binding site 1 out of 1 in the Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Structural Characterization of A Bacterial 6PDH Reveals Aspects of Specificity, Mechanism and Mode of Inhibition within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As1472 b:53.9 occ:1.00	AS	A:CAC1472	0.0	53.9	1.0
	O1	A:CAC1472	1.7	53.7	1.0
	O2	A:CAC1472	1.7	52.5	1.0
	C1	A:CAC1472	2.0	52.3	1.0
	C2	A:CAC1472	2.0	53.0	1.0
	ND1	A:HIS453	4.0	21.5	1.0
	O	A:ALA452	4.2	23.4	1.0
	O	A:HOH2290	4.4	30.6	1.0
	CA	A:HIS453	4.4	22.4	1.0
	CE1	A:HIS453	4.7	22.6	1.0
	O	A:HIS453	4.7	21.8	1.0
	O	A:GLY451	4.8	22.1	1.0
	C	A:ALA452	4.9	23.0	1.0
	C	A:HIS453	4.9	22.5	1.0

Reference:

R.Sundaramoorthy, J.Iulek, M.P.Barrett, O.Bidet, G.F.Ruda, I.H.Gilbert, W.N.Hunter. Crystal Structures of A Bacterial 6-Phosphogluconate Dehydrogenase Reveal Aspects of Specificity, Mechanism and Mode of Inhibition By Analogues of High-Energy Reaction Intermediates. Febs J. V. 274 275 2007.
ISSN: ISSN 1742-464X
PubMed: 17222187
DOI: 10.1111/J.1742-4658.2006.05585.X

Page generated: Wed Jul 10 11:27:19 2024

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