Atomistry » Arsenic » PDB 2im3-2xnq » 2jbh
Atomistry »
  Arsenic »
    PDB 2im3-2xnq »
      2jbh »

Arsenic in PDB 2jbh: Human Phosphoribosyl Transferase Domain Containing 1

Enzymatic activity of Human Phosphoribosyl Transferase Domain Containing 1

All present enzymatic activity of Human Phosphoribosyl Transferase Domain Containing 1:
2.4.2.8;

Protein crystallography data

The structure of Human Phosphoribosyl Transferase Domain Containing 1, PDB code: 2jbh was solved by M.Welin, P.Stenmark, C.Arrowsmith, H.Berglund, R.Busam, R.Collins, A.Edwards, H.Eklund, U.B.Ericsson, S.Flodin, A.Flores, S.Graslund, M.Hammarstrom, B.M.Hallberg, L.Holmberg Schiavone, M.Hogbom, I.Johansson, T.Karlberg, T.Kotenyova, M.Moche, M.E.Nilsson, T.Nyman, D.Ogg, C.Persson, J.Sagemark, M.Sundstrom, J.Uppenberg, A.G.Thorsell, S.Van Den Berg, J.Weigelt, P.Nordlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.44 / 1.7
Space group P 3 2 1
Cell size a, b, c (Å), α, β, γ (°) 139.232, 139.232, 52.132, 90.00, 90.00, 120.00
R / Rfree (%) 18.2 / 21.5

Other elements in 2jbh:

The structure of Human Phosphoribosyl Transferase Domain Containing 1 also contains other interesting chemical elements:

Calcium (Ca) 4 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Human Phosphoribosyl Transferase Domain Containing 1 (pdb code 2jbh). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Human Phosphoribosyl Transferase Domain Containing 1, PDB code: 2jbh:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 2jbh

Go back to Arsenic Binding Sites List in 2jbh
Arsenic binding site 1 out of 2 in the Human Phosphoribosyl Transferase Domain Containing 1


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Human Phosphoribosyl Transferase Domain Containing 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As82

b:21.9
occ:1.00
AS A:CAS82 0.0 21.9 1.0
CE2 A:CAS82 2.0 19.1 1.0
CE1 A:CAS82 2.0 18.0 1.0
SG A:CAS82 2.3 14.9 1.0
CB A:CAS82 3.2 12.2 1.0
C A:CAS82 3.3 12.5 1.0
N A:ALA83 3.3 10.7 1.0
O A:CAS82 3.6 11.5 1.0
CA A:ALA83 3.7 10.7 1.0
CA A:CAS82 3.8 11.9 1.0
CG2 A:VAL86 3.9 10.6 1.0
CB A:VAL86 4.5 11.1 1.0
O A:TYR79 4.5 10.8 1.0
CB A:ALA83 4.5 10.9 1.0
CE2 A:PHE106 4.7 13.9 1.0
O A:HOH2073 4.8 11.1 1.0
C A:ALA83 4.8 10.8 1.0
CB A:CYS73 4.9 12.0 1.0
SG A:CYS73 4.9 14.7 1.0
N A:CAS82 5.0 11.4 1.0

Arsenic binding site 2 out of 2 in 2jbh

Go back to Arsenic Binding Sites List in 2jbh
Arsenic binding site 2 out of 2 in the Human Phosphoribosyl Transferase Domain Containing 1


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Human Phosphoribosyl Transferase Domain Containing 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As82

b:21.0
occ:1.00
AS B:CAS82 0.0 21.0 1.0
CE2 B:CAS82 2.0 19.1 1.0
CE1 B:CAS82 2.0 17.7 1.0
SG B:CAS82 2.3 14.6 1.0
CB B:CAS82 3.2 12.2 1.0
C B:CAS82 3.3 10.8 1.0
N B:ALA83 3.4 11.1 1.0
O B:CAS82 3.6 10.1 1.0
CA B:ALA83 3.7 10.6 1.0
CA B:CAS82 3.8 11.1 1.0
CG2 B:VAL86 4.0 11.1 1.0
CB B:VAL86 4.5 10.8 1.0
O B:TYR79 4.5 10.3 1.0
CB B:ALA83 4.6 11.4 1.0
CE2 B:PHE106 4.7 16.1 1.0
CB B:CYS73 4.7 12.1 1.0
C B:ALA83 4.8 11.0 1.0
SG B:CYS73 4.9 13.9 1.0
N B:CAS82 4.9 10.8 1.0
CZ B:PHE106 5.0 14.4 1.0

Reference:

M.Welin, L.Egeblad, A.Johansson, P.Stenmark, L.Wang, S.Flodin, T.Nyman, L.Tresaugues, T.Kotenyova, I.Johansson, S.Eriksson, H.Eklund, P.Nordlund. Structural and Functional Studies of the Human Phosphoribosyltransferase Domain Containing Protein 1. Febs J. V. 277 4920 2010.
ISSN: ISSN 1742-464X
PubMed: 21054786
DOI: 10.1111/J.1742-4658.2010.07897.X
Page generated: Tue Oct 27 16:49:10 2020

Last articles

Xe in 6AYK
Xe in 6QII
Xe in 6ASM
Xe in 5NSW
Xe in 6FY9
Xe in 5O1K
Xe in 5O27
Xe in 5M69
Xe in 5KPU
Xe in 5I63
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy