Atomistry » Arsenic » PDB 2im3-2xnq » 2oui
Atomistry »
  Arsenic »
    PDB 2im3-2xnq »
      2oui »

Arsenic in PDB 2oui: D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica

Enzymatic activity of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica

All present enzymatic activity of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica:
1.1.1.2;

Protein crystallography data

The structure of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica, PDB code: 2oui was solved by F.Frolow, L.Shimon, Y.Burstein, E.Goihberg, M.Peretz, O.Dym, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.77
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 145.921, 144.104, 80.073, 90.00, 121.44, 90.00
R / Rfree (%) 14.8 / 17.8

Other elements in 2oui:

The structure of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Zinc (Zn) 4 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica (pdb code 2oui). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 4 binding sites of Arsenic where determined in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica, PDB code: 2oui:
Jump to Arsenic binding site number: 1; 2; 3; 4;

Arsenic binding site 1 out of 4 in 2oui

Go back to Arsenic Binding Sites List in 2oui
Arsenic binding site 1 out of 4 in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As1001

b:26.5
occ:1.00
 AS A:CAC1001 0.0 26.5 1.0
O1 A:CAC1001 1.7 25.5 1.0
O2 A:CAC1001 1.8 19.1 1.0
C1 A:CAC1001 2.0 26.5 1.0
C2 A:CAC1001 2.0 28.7 1.0
ZN A:ZN361 3.2 19.4 1.0
OD1 A:ASP150 3.5 30.4 1.0
OG A:SER39 3.6 29.9 1.0
O A:HOH5042 3.7 18.9 1.0
OD2 A:ASP150 3.7 27.1 1.0
CG A:ASP150 4.0 27.4 1.0
C1 A:EDO2001 4.1 33.6 1.0
NE2 A:HIS59 4.1 24.1 1.0
CB A:SER39 4.5 24.2 1.0
C2 A:EDO2001 4.6 30.7 1.0
CD2 A:HIS59 4.7 22.4 1.0
CZ2 A:TRP110 4.7 30.7 1.0
OG1 A:THR154 4.8 24.9 1.0
CE2 A:TRP110 4.8 30.2 1.0
CD1 A:LEU294 4.8 24.4 1.0
CE1 A:HIS59 4.8 22.5 1.0
CH2 A:TRP110 4.9 31.7 1.0
SG A:CYS37 4.9 26.1 1.0
CD2 A:TRP110 5.0 26.3 1.0

Arsenic binding site 2 out of 4 in 2oui

Go back to Arsenic Binding Sites List in 2oui
Arsenic binding site 2 out of 4 in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As1001

b:24.4
occ:1.00
 AS B:CAC1001 0.0 24.4 1.0
O1 B:CAC1001 1.7 24.5 1.0
O2 B:CAC1001 1.8 20.4 1.0
C2 B:CAC1001 1.9 19.8 1.0
C1 B:CAC1001 2.0 29.1 1.0
ZN B:ZN361 3.2 19.4 1.0
OD1 B:ASP150 3.5 32.2 1.0
OD2 B:ASP150 3.6 28.4 1.0
O B:HOH5067 3.7 17.2 1.0
OG B:SER39 3.8 30.1 1.0
CG B:ASP150 4.0 26.7 1.0
NE2 B:HIS59 4.1 25.2 1.0
O B:HOH5008 4.5 34.5 1.0
CB B:SER39 4.6 24.4 1.0
OG1 B:THR154 4.7 23.1 1.0
CD2 B:HIS59 4.7 22.3 1.0
CD1 B:LEU294 4.8 21.2 1.0
CZ2 B:TRP110 4.8 23.1 1.0
CE1 B:HIS59 4.8 24.1 1.0
CE2 B:TRP110 4.8 25.1 1.0
CH2 B:TRP110 4.9 29.0 1.0
SG B:CYS37 4.9 25.7 1.0
CD2 B:TRP110 5.0 21.0 1.0

Arsenic binding site 3 out of 4 in 2oui

Go back to Arsenic Binding Sites List in 2oui
Arsenic binding site 3 out of 4 in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica within 5.0Å range:
probe atom residue distance (Å) B Occ
C:As1001

b:24.5
occ:1.00
 AS C:CAC1001 0.0 24.5 1.0
O1 C:CAC1001 1.7 23.9 1.0
O2 C:CAC1001 1.8 29.4 1.0
C2 C:CAC1001 1.9 19.4 1.0
C1 C:CAC1001 1.9 16.9 1.0
ZN C:ZN361 3.2 18.9 1.0
OD1 C:ASP150 3.6 28.3 1.0
O C:HOH5052 3.7 17.6 1.0
OG C:SER39 3.7 24.2 1.0
OD2 C:ASP150 3.8 31.0 1.0
CG C:ASP150 4.1 23.8 1.0
NE2 C:HIS59 4.1 23.2 1.0
CB C:SER39 4.5 24.4 1.0
CE1 C:HIS59 4.7 24.2 1.0
OG1 C:THR154 4.7 24.1 1.0
CZ2 C:TRP110 4.8 26.5 1.0
CD1 C:LEU294 4.8 20.9 1.0
CE2 C:TRP110 4.8 25.5 1.0
CD2 C:HIS59 4.8 21.8 1.0
O C:HOH5015 4.8 34.6 1.0
SG C:CYS37 4.9 25.1 1.0
CH2 C:TRP110 5.0 25.2 1.0

Arsenic binding site 4 out of 4 in 2oui

Go back to Arsenic Binding Sites List in 2oui
Arsenic binding site 4 out of 4 in the D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of D275P Mutant of Alcohol Dehydrogenase From Protozoa Entamoeba Histolytica within 5.0Å range:
probe atom residue distance (Å) B Occ
D:As1001

b:25.3
occ:1.00
 AS D:CAC1001 0.0 25.3 1.0
O2 D:CAC1001 1.7 21.6 1.0
O1 D:CAC1001 1.8 22.5 1.0
C1 D:CAC1001 2.0 22.7 1.0
C2 D:CAC1001 2.0 26.6 1.0
ZN D:ZN361 3.3 19.8 1.0
OD1 D:ASP150 3.6 33.6 1.0
OD2 D:ASP150 3.7 29.3 1.0
O D:HOH7023 3.7 20.7 1.0
OG D:SER39 3.8 27.3 1.0
CG D:ASP150 4.0 29.8 1.0
NE2 D:HIS59 4.1 21.7 1.0
CB D:SER39 4.4 21.7 1.0
CZ2 D:TRP110 4.6 26.8 1.0
OG1 D:THR154 4.7 27.0 1.0
CE2 D:TRP110 4.7 29.6 1.0
O D:HOH7053 4.7 37.5 1.0
CD2 D:HIS59 4.8 26.7 1.0
CE1 D:HIS59 4.8 23.0 1.0
CD1 D:LEU294 4.8 21.6 1.0
CH2 D:TRP110 4.8 29.9 1.0
SG D:CYS37 4.9 21.9 1.0
CD2 D:TRP110 5.0 28.1 1.0

Reference:

E.Goihberg, O.Dym, S.Tel-Or, L.Shimon, F.Frolow, M.Peretz, Y.Burstein. Thermal Stabilization of the Protozoan Entamoeba Histolytica Alcohol Dehydrogenase By A Single Proline Substitution. Proteins V. 72 711 2008.
ISSN: ISSN 0887-3585
PubMed: 18260103
DOI: 10.1002/PROT.21946
Page generated: Tue Oct 27 16:49:15 2020

Last articles

Xe in 6AYK
Xe in 6QII
Xe in 6ASM
Xe in 5NSW
Xe in 6FY9
Xe in 5O1K
Xe in 5O27
Xe in 5M69
Xe in 5KPU
Xe in 5I63
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy