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Arsenic in PDB 3h6t: Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution

Protein crystallography data

The structure of Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution, PDB code: 3h6t was solved by H.Hald, M.Gajhede, J.S.Kastrup, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.84 / 2.25
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 114.486, 163.136, 47.354, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 22.8

Other elements in 3h6t:

The structure of Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Zinc (Zn) 10 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution (pdb code 3h6t). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution, PDB code: 3h6t:

Arsenic binding site 1 out of 1 in 3h6t

Go back to Arsenic Binding Sites List in 3h6t
Arsenic binding site 1 out of 1 in the Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of the IGLUR2 Ligand-Binding Core (S1S2J-N754S) in Complex with Glutamate and Cyclothiazide at 2.25 A Resolution within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As274

b:59.3
occ:1.00
AS B:CAC274 0.0 59.3 1.0
O2 B:CAC274 1.6 58.3 1.0
O1 B:CAC274 1.8 59.0 1.0
C1 B:CAC274 2.0 57.5 1.0
C2 B:CAC274 2.0 57.8 1.0
ZN A:ZN266 3.2 28.0 1.0
CB B:SER168 4.0 21.2 1.0
NE2 A:HIS46 4.1 32.1 1.0
O B:HOH901 4.2 53.1 1.0
OG B:SER168 4.2 24.0 1.0
OE2 B:GLU166 4.2 21.2 1.0
O B:HOH304 4.2 15.5 1.0
CA B:SER168 4.3 21.1 1.0
O B:ALA165 4.3 24.8 1.0
CE1 A:HIS46 4.3 32.1 1.0
OE1 B:GLU166 4.6 19.4 1.0
CE A:LYS45 4.6 40.8 1.0
CD B:GLU166 4.7 19.4 1.0
N B:SER168 4.8 22.0 1.0
CD A:LYS45 4.8 38.0 1.0
OE1 A:GLU42 4.8 27.5 1.0
O B:ARG163 4.9 24.7 1.0
CD2 A:HIS46 4.9 30.8 1.0
CG A:LYS45 5.0 35.3 1.0

Reference:

H.Hald, P.K.Ahring, D.B.Timmermann, T.Liljefors, M.Gajhede, J.S.Kastrup. Distinct Structural Features of Cyclothiazide Are Responsible For Effects on Peak Current Amplitude and Desensitization Kinetics at IGLUR2. J.Mol.Biol. V. 391 906 2009.
ISSN: ISSN 0022-2836
PubMed: 19591837
DOI: 10.1016/J.JMB.2009.07.002
Page generated: Tue Oct 27 16:50:21 2020

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