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Atomistry » Arsenic » PDB 3sr6-4cx0 » 4cu1 » |
Arsenic in PDB 4cu1: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-AmineEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine, PDB code: 4cu1
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4cu1:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine also contains other interesting chemical elements:
Arsenic Binding Sites:
The binding sites of Arsenic atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine
(pdb code 4cu1). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine, PDB code: 4cu1: Arsenic binding site 1 out of 1 in 4cu1Go back to Arsenic Binding Sites List in 4cu1
Arsenic binding site 1 out
of 1 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 6-[(2S)-3-Amino-2-{5-[2-(6-Amino- 4-Methylpyridin-2-Yl)Ethyl]Pyridin-3-Yl}Propyl]-4- Methylpyridin-2-Amine
Mono view Stereo pair view
Reference:
S.Kang,
W.Tang,
H.Li,
G.Chreifi,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Nitric Oxide Synthase Inhibitors That Interact with Both A Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem. V. 57 4382 2014.
Page generated: Sat Dec 12 01:42:45 2020
ISSN: ISSN 0022-2623 PubMed: 24758147 DOI: 10.1021/JM5004182 |
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