Atomistry » Arsenic » PDB 3sr6-4cx0 » 4cvg
Atomistry »
  Arsenic »
    PDB 3sr6-4cx0 »
      4cvg »

Arsenic in PDB 4cvg: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One.

Enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One.

All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One.:
1.14.13.39;

Protein crystallography data

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One., PDB code: 4cvg was solved by G.Chreifi, H.Li, T.L.Poulos, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.31
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.414, 105.957, 156.530, 90.00, 90.00, 90.00
R / Rfree (%) 15.479 / 21.358

Other elements in 4cvg:

The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One. also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One. (pdb code 4cvg). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One., PDB code: 4cvg:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 4cvg

Go back to Arsenic Binding Sites List in 4cvg
Arsenic binding site 1 out of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As384

b:70.3
occ:1.00
 AS A:CAS384 0.0 70.3 1.0
CE2 A:CAS384 2.0 61.8 1.0
CE1 A:CAS384 2.0 54.9 1.0
SG A:CAS384 2.5 50.4 1.0
CB A:CAS384 3.1 41.8 1.0
CA A:CAS384 3.8 41.2 1.0
CE3 A:TRP324 4.3 36.0 1.0
CD2 A:TRP324 4.4 39.5 1.0
CG A:TRP324 4.6 38.7 1.0
CB A:TRP324 4.6 40.0 1.0
N A:CAS384 4.7 42.8 1.0
CD1 A:LEU328 4.9 40.9 1.0
C A:CAS384 4.9 40.9 1.0
CZ3 A:TRP324 5.0 36.4 1.0

Arsenic binding site 2 out of 2 in 4cvg

Go back to Arsenic Binding Sites List in 4cvg
Arsenic binding site 2 out of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain (H4B-Free) Supplemented with 50UM Zn Acetate and with Poor Binding of 6-Acetyl-2-Amino-7,7-Dimethyl-7,8-Dihydropteridin-4(3H)-One. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As384

b:67.7
occ:1.00
 AS B:CAS384 0.0 67.7 1.0
CE2 B:CAS384 2.0 61.7 1.0
CE1 B:CAS384 2.0 55.1 1.0
SG B:CAS384 2.5 61.0 1.0
CB B:CAS384 3.0 48.9 1.0
CA B:CAS384 3.8 51.6 1.0
CE3 B:TRP324 4.2 46.8 1.0
CB B:TRP324 4.3 50.7 1.0
CD2 B:TRP324 4.3 48.8 1.0
CG B:TRP324 4.4 51.4 1.0
N B:CAS384 4.7 53.4 1.0
C B:CAS384 4.8 51.4 1.0
CD2 B:LEU328 4.9 52.9 1.0
CZ3 B:TRP324 4.9 43.9 1.0
O B:CAS384 5.0 54.9 1.0

Reference:

G.Chreifi, H.Li, C.R.Mcinnes, C.L.Gibson, C.J.Suckling, T.L.Poulos. Communication Between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry V. 53 4216 2014.
ISSN: ISSN 0006-2960
PubMed: 24819538
DOI: 10.1021/BI5003986
Page generated: Wed Jul 10 12:02:20 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy