Atomistry » Arsenic » PDB 4cx1-4j8m » 4eg3
Atomistry »
  Arsenic »
    PDB 4cx1-4j8m »
      4eg3 »

Arsenic in PDB 4eg3: Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate

Enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate

All present enzymatic activity of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate:
6.1.1.10;

Protein crystallography data

The structure of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate, PDB code: 4eg3 was solved by C.Y.Koh, J.E.Kim, S.Shibata, E.Fan, C.L.M.J.Verlinde, W.G.J.Hol, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 2.94
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 85.477, 105.908, 208.445, 90.00, 90.00, 90.00
R / Rfree (%) 21.2 / 26.6

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate (pdb code 4eg3). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate, PDB code: 4eg3:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 4eg3

Go back to Arsenic Binding Sites List in 4eg3
Arsenic binding site 1 out of 2 in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As470

b:57.5
occ:0.40
AS A:CAS470 0.0 57.5 0.4
CE1 A:CAS470 2.0 58.5 0.4
CE2 A:CAS470 2.0 58.5 0.4
SG A:CAS470 2.2 57.1 1.0
CB A:CAS470 3.1 56.0 1.0
O A:ALA460 3.2 55.3 1.0
O A:HIS469 3.8 54.9 1.0
CA A:CAS470 4.0 54.9 1.0
C A:ALA460 4.1 55.1 1.0
CA A:PRO462 4.1 54.6 1.0
N A:PRO462 4.2 55.2 1.0
N A:CAS470 4.3 53.9 1.0
C A:HIS469 4.4 54.3 1.0
CG A:ARG453 4.4 67.1 1.0
CG A:PRO462 4.4 57.5 1.0
C A:ILE461 4.5 54.2 1.0
O A:ASN458 4.5 62.0 1.0
N A:ALA460 4.5 56.5 1.0
C A:ASN458 4.5 61.4 1.0
CA A:ASN458 4.5 63.5 1.0
CD A:ARG453 4.6 69.7 1.0
CB A:PRO462 4.6 56.3 1.0
CD A:PRO462 4.6 56.5 1.0
O A:ILE461 4.7 53.1 1.0
CA A:ALA460 4.7 55.1 1.0
O A:PRO467 4.8 61.8 1.0
CB A:ARG453 4.9 64.0 1.0
CB A:ALA460 4.9 53.6 1.0

Arsenic binding site 2 out of 2 in 4eg3

Go back to Arsenic Binding Sites List in 4eg3
Arsenic binding site 2 out of 2 in the Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Trypanosoma Brucei Methionyl-Trna Synthetase in Complex with Product Methionyl-Adenylate within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As470

b:64.5
occ:0.40
AS B:CAS470 0.0 64.5 0.4
CE1 B:CAS470 2.0 68.4 0.4
CE2 B:CAS470 2.0 68.5 0.4
SG B:CAS470 2.2 66.0 1.0
CB B:CAS470 3.1 63.3 1.0
CA B:CAS470 3.7 61.0 1.0
CG B:ARG453 3.8 85.8 1.0
CZ B:ARG453 3.9 87.1 1.0
NH1 B:ARG453 3.9 86.4 1.0
NE B:ARG453 4.0 87.9 1.0
CD B:PRO462 4.0 62.4 1.0
O B:HIS469 4.0 63.2 1.0
N B:PRO462 4.0 60.2 1.0
CA B:PRO462 4.0 61.1 1.0
CG B:PRO462 4.1 64.1 1.0
CD B:ARG453 4.2 87.0 1.0
N B:CAS470 4.3 62.2 1.0
C B:HIS469 4.3 63.6 1.0
C B:ILE461 4.4 58.3 1.0
NH2 B:ARG453 4.4 87.5 1.0
CB B:ARG453 4.4 84.8 1.0
O B:ALA460 4.4 60.1 1.0
CB B:PRO462 4.5 63.3 1.0
O B:ILE461 4.5 58.6 1.0
CA B:ARG453 4.6 83.0 1.0
C B:ALA460 4.7 59.7 1.0
O B:PRO467 4.8 76.8 1.0

Reference:

C.Y.Koh, J.E.Kim, S.Shibata, R.M.Ranade, M.Yu, J.Liu, J.R.Gillespie, F.S.Buckner, C.L.Verlinde, E.Fan, W.G.Hol. Distinct States of Methionyl-Trna Synthetase Indicate Inhibitor Binding By Conformational Selection. Structure V. 20 1681 2012.
ISSN: ISSN 0969-2126
PubMed: 22902861
DOI: 10.1016/J.STR.2012.07.011
Page generated: Sat Dec 12 01:43:18 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy