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Arsenic in PDB 4gk8: Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

Enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate

All present enzymatic activity of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate:
3.1.3.15;

Protein crystallography data

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8 was solved by A.A.Fedorov, E.V.Fedorov, S.Ghodge, F.M.Raushel, S.C.Almo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.31 / 1.93
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 85.860, 86.622, 45.093, 90.00, 90.00, 90.00
R / Rfree (%) 16.2 / 19.6

Other elements in 4gk8:

The structure of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Zinc (Zn) 4 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate (pdb code 4gk8). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate, PDB code: 4gk8:

Arsenic binding site 1 out of 1 in 4gk8

Go back to Arsenic Binding Sites List in 4gk8
Arsenic binding site 1 out of 1 in the Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Histidinol Phosphate Phosphatase (Hisk) From Lactococcus Lactis Subsp. Lactis IL1403 Complexed with Zn and L- Histidinol Arsenate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As305

b:24.1
occ:0.85
 AS A:GK8305 0.0 24.1 0.8
O1 A:GK8305 1.8 21.2 0.8
O3 A:GK8305 1.8 21.4 0.8
O2 A:GK8305 1.8 21.9 0.8
O4 A:GK8305 1.8 19.2 0.8
O A:HOH575 2.7 23.9 1.0
C A:GK8305 2.8 28.7 0.8
ZN A:ZN302 3.1 19.9 1.0
ZN A:ZN303 3.2 17.4 0.8
ZN A:ZN301 3.2 15.9 0.9
CE1 A:HIS42 3.7 16.7 1.0
OD1 A:ASP228 3.8 19.9 1.0
CA A:GK8305 3.8 24.8 0.8
N A:GK8305 3.8 21.1 0.8
NE2 A:HIS42 3.8 16.8 1.0
O A:HOH557 3.8 39.2 1.0
CE1 A:HIS230 3.9 21.7 1.0
OD2 A:ASP228 3.9 17.9 1.0
NE2 A:HIS230 4.0 18.5 1.0
NH1 A:ARG160 4.0 21.8 1.0
OE1 A:GLU81 4.2 16.3 1.0
CG A:ASP228 4.2 20.7 1.0
CE1 A:TYR157 4.4 20.6 1.0
NE2 A:HIS109 4.5 19.3 1.0
NE2 A:HIS11 4.5 15.7 1.0
NH2 A:ARG197 4.5 30.4 1.0
OE2 A:GLU81 4.6 17.1 1.0
OD2 A:ASP17 4.6 16.9 1.0
NE2 A:HIS154 4.7 17.5 1.0
CD A:GLU81 4.8 19.0 1.0
OH A:TYR157 4.9 23.6 1.0
ND1 A:HIS42 5.0 16.4 1.0

Reference:

S.V.Ghodge, A.A.Fedorov, E.V.Fedorov, B.Hillerich, R.Seidel, S.C.Almo, F.M.Raushel. Structural and Mechanistic Characterization of L-Histidinol Phosphate Phosphatase From the Polymerase and Histidinol Phosphatase Family of Proteins. Biochemistry V. 52 1101 2013.
ISSN: ISSN 0006-2960
PubMed: 23327428
DOI: 10.1021/BI301496P
Page generated: Wed Jul 10 12:09:01 2024

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