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Arsenic in PDB 4k4g: Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp.

Enzymatic activity of Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp.

All present enzymatic activity of Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp.:
2.7.7.7;

Protein crystallography data

The structure of Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp., PDB code: 4k4g was solved by R.Vyas, Z.Suo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 36.60 / 2.15
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 194.570, 97.810, 105.070, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 25

Other elements in 4k4g:

The structure of Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp. also contains other interesting chemical elements:

Calcium (Ca) 22 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp. (pdb code 4k4g). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp., PDB code: 4k4g:

Arsenic binding site 1 out of 1 in 4k4g

Go back to Arsenic Binding Sites List in 4k4g
Arsenic binding site 1 out of 1 in the Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Ternary Crystal Structures of Human Dna Polymerase Lambda in Complex with Dna and L-Dctp. within 5.0Å range:
probe atom residue distance (Å) B Occ
M:As607

b:0.4
occ:1.00
AS M:CAC607 0.0 0.4 1.0
O1 M:CAC607 1.7 0.8 1.0
O2 M:CAC607 1.7 96.7 1.0
C1 M:CAC607 2.0 0.7 1.0
C2 M:CAC607 2.0 0.3 1.0
O M:GLU318 2.8 37.5 1.0
C M:GLU318 3.9 39.0 1.0
CA M:GLU318 4.5 43.7 1.0

Reference:

R.Vyas, W.J.Zahurancik, Z.Suo. Structural Basis For the Binding and Incorporation of Nucleotide Analogs with L-Stereochemistry By Human Dna Polymerase Lambda. Proc.Natl.Acad.Sci.Usa V. 111 E3033 2014.
ISSN: ISSN 0027-8424
PubMed: 25015085
DOI: 10.1073/PNAS.1401286111
Page generated: Wed Jul 10 12:12:59 2024

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