Arsenic in PDB 4k4i: Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp.

All present enzymatic activity of Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp.:
2.7.7.7;

The structure of Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp., PDB code: 4k4i was solved by R.Vyas, Z.Suo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.03 / 2.25
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	194.440, 97.580, 105.150, 90.00, 90.00, 90.00
R / Rfree (%)	21.2 / 27.4

The structure of Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp. also contains other interesting chemical elements:

Fluorine	(F)	4 atoms
Calcium	(Ca)	23 atoms

The binding sites of Arsenic atom in the Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp. (pdb code 4k4i). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp., PDB code: 4k4i:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp. within 5.0Å range: probe atom residue distance (Å) B Occ E:As607 b:0.0 occ:1.00 AS E:CAC607 0.0 0.0 1.0 O1 E:CAC607 1.7 0.6 1.0 O2 E:CAC607 1.7 1.0 1.0 C2 E:CAC607 2.0 0.1 1.0 C1 E:CAC607 2.0 0.1 1.0 O F:HOH209 3.3 61.5 1.0 OG E:SER463 3.4 49.5 1.0 NH2 I:ARG441 4.2 74.1 1.0 CG E:GLU465 4.4 71.2 1.0 CB E:SER463 4.4 43.7 1.0 O E:HOH763 4.5 56.0 1.0

Arsenic binding site 2 out of 2 in the Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Ternary Crystal Structures of A Human Dna Polymerase Lambda in Complex with Dna and (-)Ftc-Tp. within 5.0Å range: probe atom residue distance (Å) B Occ M:As606 b:88.2 occ:1.00 AS M:CAC606 0.0 88.2 1.0 O2 M:CAC606 1.7 74.8 1.0 O1 M:CAC606 1.7 82.4 1.0 C1 M:CAC606 2.0 77.8 1.0 C2 M:CAC606 2.0 77.9 1.0 O M:GLU318 2.7 34.8 1.0 O M:HOH812 3.0 44.4 1.0 O M:HOH814 3.1 51.9 1.0 C M:GLU318 3.9 32.2 1.0 O M:HOH800 4.3 51.3 1.0 CA M:GLU318 4.6 32.5 1.0 N M:SER319 4.9 31.0 1.0

R.Vyas, W.J.Zahurancik, Z.Suo. Structural Basis For the Binding and Incorporation of Nucleotide Analogs with L-Stereochemistry By Human Dna Polymerase Lambda. Proc.Natl.Acad.Sci.Usa V. 111 E3033 2014.
ISSN: ISSN 0027-8424
PubMed: 25015085
DOI: 10.1073/PNAS.1401286111