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Atomistry » Arsenic » PDB 4mwd-4uha » 4uh8 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Arsenic » PDB 4mwd-4uha » 4uh8 » |
Arsenic in PDB 4uh8: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-DiamineEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine, PDB code: 4uh8
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uh8:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine also contains other interesting chemical elements:
Arsenic Binding Sites:
The binding sites of Arsenic atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
(pdb code 4uh8). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine, PDB code: 4uh8: Jump to Arsenic binding site number: 1; 2; Arsenic binding site 1 out of 2 in 4uh8Go back to Arsenic Binding Sites List in 4uh8
Arsenic binding site 1 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
Mono view Stereo pair view
Arsenic binding site 2 out of 2 in 4uh8Go back to Arsenic Binding Sites List in 4uh8
Arsenic binding site 2 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with N1-(5-(2-(6-Amino-4-Methylpyridin-2- Yl)Ethyl)Pyridin-3-Yl)-N1,N2-Dimethylethane-1,2-Diamine
Mono view Stereo pair view
Reference:
S.Kang,
H.Li,
W.Tang,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J.Med.Chem. V. 58 5548 2015.
Page generated: Wed Jul 10 12:27:34 2024
ISSN: ISSN 0022-2623 PubMed: 26120733 DOI: 10.1021/ACS.JMEDCHEM.5B00573 |
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