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Atomistry » Arsenic » PDB 4mwd-4uha » 4uha | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Arsenic » PDB 4mwd-4uha » 4uha » |
Arsenic in PDB 4uha: Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)BenzonitrileEnzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile
All present enzymatic activity of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile:
1.14.13.39; Protein crystallography data
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile, PDB code: 4uha
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4uha:
The structure of Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile also contains other interesting chemical elements:
Arsenic Binding Sites:
The binding sites of Arsenic atom in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile
(pdb code 4uha). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile, PDB code: 4uha: Jump to Arsenic binding site number: 1; 2; Arsenic binding site 1 out of 2 in 4uhaGo back to Arsenic Binding Sites List in 4uha
Arsenic binding site 1 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile
Mono view Stereo pair view
Arsenic binding site 2 out of 2 in 4uhaGo back to Arsenic Binding Sites List in 4uha
Arsenic binding site 2 out
of 2 in the Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in Complex with 3-(2-(6-Amino-4-Methylpyridin-2-Yl)Ethyl)-5-(Methyl(2- (Methylamino)Ethyl)Amino)Benzonitrile
Mono view Stereo pair view
Reference:
S.Kang,
H.Li,
W.Tang,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity. J. Med. Chem. V. 58 5548 2015.
Page generated: Wed Jul 10 12:27:55 2024
ISSN: ISSN 1520-4804 PubMed: 26120733 DOI: 10.1021/ACS.JMEDCHEM.5B00573 |
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