Arsenic in PDB 4w9i: Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Protein crystallography data
The structure of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10), PDB code: 4w9i
was solved by
M.S.Gadd,
P.Soares,
C.Galdeano,
I.Van Molle,
A.Ciulli,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
93.40 /
2.40
|
Space group
|
P 41 2 2
|
Cell size a, b, c (Å), α, β, γ (°)
|
93.402,
93.402,
364.322,
90.00,
90.00,
90.00
|
R / Rfree (%)
|
22.5 /
27.5
|
Arsenic Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
12;
Binding sites:
The binding sites of Arsenic atom in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
(pdb code 4w9i). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total 12 binding sites of Arsenic where determined in the
Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10), PDB code: 4w9i:
Jump to Arsenic binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Arsenic binding site 1 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 1 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 1 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:As60
b:54.4
occ:1.00
|
AS
|
A:CAS60
|
0.0
|
54.4
|
1.0
|
CE2
|
A:CAS60
|
2.0
|
57.4
|
1.0
|
CE1
|
A:CAS60
|
2.0
|
58.4
|
1.0
|
SG
|
A:CAS60
|
2.3
|
42.0
|
1.0
|
CB
|
A:CAS60
|
3.2
|
35.6
|
1.0
|
CA
|
A:CAS60
|
3.4
|
34.6
|
1.0
|
CD2
|
A:LEU51
|
3.8
|
38.0
|
1.0
|
N
|
A:CAS60
|
4.1
|
32.9
|
1.0
|
O
|
A:GLU59
|
4.5
|
33.5
|
1.0
|
CB
|
A:LYS55
|
4.5
|
31.1
|
1.0
|
CG
|
A:LYS55
|
4.5
|
33.9
|
1.0
|
C
|
A:GLU59
|
4.5
|
34.1
|
1.0
|
NE2
|
A:GLN49
|
4.6
|
42.8
|
1.0
|
C
|
A:CAS60
|
4.7
|
34.4
|
1.0
|
O
|
A:CAS60
|
4.9
|
35.5
|
1.0
|
CD
|
A:GLN49
|
5.0
|
41.5
|
1.0
|
|
Arsenic binding site 2 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 2 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 2 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:As89
b:65.8
occ:1.00
|
AS
|
A:CAS89
|
0.0
|
65.8
|
1.0
|
CE2
|
A:CAS89
|
2.0
|
65.6
|
1.0
|
CE1
|
A:CAS89
|
2.0
|
66.9
|
1.0
|
SG
|
A:CAS89
|
2.2
|
54.4
|
1.0
|
CB
|
A:CAS89
|
3.0
|
50.8
|
1.0
|
CA
|
A:CAS89
|
3.5
|
45.9
|
1.0
|
C
|
A:CAS89
|
4.0
|
41.0
|
1.0
|
N
|
A:ILE90
|
4.1
|
39.3
|
1.0
|
OE2
|
A:GLU91
|
4.4
|
59.5
|
1.0
|
O
|
A:ILE90
|
4.6
|
37.2
|
1.0
|
C
|
A:ILE90
|
4.7
|
38.1
|
1.0
|
N
|
A:CAS89
|
4.8
|
45.2
|
1.0
|
O
|
A:CAS89
|
4.9
|
39.3
|
1.0
|
O
|
A:LEU88
|
5.0
|
50.0
|
1.0
|
|
Arsenic binding site 3 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 3 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 3 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:As77
b:47.0
occ:1.00
|
AS
|
C:CAS77
|
0.0
|
47.0
|
1.0
|
CE2
|
C:CAS77
|
2.0
|
47.3
|
1.0
|
CE1
|
C:CAS77
|
2.0
|
46.0
|
1.0
|
SG
|
C:CAS77
|
2.2
|
38.6
|
1.0
|
CB
|
C:CAS77
|
3.1
|
34.9
|
1.0
|
CA
|
C:CAS77
|
3.5
|
31.2
|
1.0
|
CA
|
C:GLY106
|
4.1
|
34.8
|
1.0
|
O
|
C:THR105
|
4.2
|
34.6
|
1.0
|
C
|
C:CAS77
|
4.3
|
30.5
|
1.0
|
N
|
C:GLY106
|
4.4
|
35.4
|
1.0
|
N
|
C:ASN78
|
4.4
|
30.3
|
1.0
|
C
|
C:THR105
|
4.4
|
35.2
|
1.0
|
CZ
|
C:PHE148
|
4.4
|
49.4
|
1.0
|
CZ
|
K:PHE109
|
4.6
|
43.4
|
1.0
|
CE
|
K:MET45
|
4.6
|
73.1
|
1.0
|
CE2
|
C:PHE148
|
4.7
|
49.3
|
1.0
|
N
|
C:CAS77
|
4.7
|
28.9
|
1.0
|
O
|
C:PHE76
|
4.8
|
29.3
|
1.0
|
CG2
|
C:ILE75
|
4.9
|
33.4
|
1.0
|
|
Arsenic binding site 4 out
of 12 in 4w9i
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Arsenic Binding Sites List in 4w9i
Arsenic binding site 4 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 4 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:As60
b:54.2
occ:1.00
|
AS
|
D:CAS60
|
0.0
|
54.2
|
1.0
|
CE1
|
D:CAS60
|
2.0
|
57.1
|
1.0
|
CE2
|
D:CAS60
|
2.0
|
56.1
|
1.0
|
SG
|
D:CAS60
|
2.2
|
46.4
|
1.0
|
CB
|
D:CAS60
|
3.1
|
40.2
|
1.0
|
CA
|
D:CAS60
|
3.3
|
36.8
|
1.0
|
N
|
D:CAS60
|
4.0
|
35.7
|
1.0
|
CD2
|
D:LEU51
|
4.2
|
43.6
|
1.0
|
O
|
D:GLU59
|
4.3
|
35.3
|
1.0
|
C
|
D:GLU59
|
4.4
|
35.4
|
1.0
|
NE2
|
D:GLN49
|
4.5
|
44.2
|
1.0
|
C
|
D:CAS60
|
4.6
|
34.7
|
1.0
|
CB
|
D:LYS55
|
4.7
|
46.5
|
1.0
|
CG
|
D:LYS55
|
4.8
|
48.3
|
1.0
|
O
|
D:CAS60
|
4.8
|
34.2
|
1.0
|
CD
|
D:GLN49
|
5.0
|
43.6
|
1.0
|
|
Arsenic binding site 5 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 5 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 5 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:As89
b:98.7
occ:1.00
|
AS
|
D:CAS89
|
0.0
|
98.7
|
1.0
|
CE2
|
D:CAS89
|
2.0
|
0.6
|
1.0
|
CE1
|
D:CAS89
|
2.0
|
98.0
|
1.0
|
SG
|
D:CAS89
|
2.2
|
89.6
|
1.0
|
CB
|
D:CAS89
|
3.1
|
81.6
|
1.0
|
CA
|
D:CAS89
|
3.5
|
72.7
|
1.0
|
N
|
D:ILE90
|
4.1
|
64.9
|
1.0
|
C
|
D:CAS89
|
4.1
|
67.7
|
1.0
|
C
|
D:ILE90
|
4.8
|
63.5
|
1.0
|
O
|
D:ILE90
|
4.8
|
62.8
|
1.0
|
N
|
D:CAS89
|
4.9
|
69.5
|
1.0
|
O
|
D:LEU88
|
5.0
|
69.0
|
1.0
|
|
Arsenic binding site 6 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 6 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 6 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
F:As77
b:47.9
occ:1.00
|
AS
|
F:CAS77
|
0.0
|
47.9
|
1.0
|
CE2
|
F:CAS77
|
2.0
|
48.9
|
1.0
|
CE1
|
F:CAS77
|
2.0
|
47.4
|
1.0
|
SG
|
F:CAS77
|
2.2
|
39.8
|
1.0
|
CB
|
F:CAS77
|
3.1
|
36.3
|
1.0
|
CA
|
F:CAS77
|
3.6
|
33.2
|
1.0
|
CA
|
F:GLY106
|
4.1
|
39.7
|
1.0
|
O
|
F:THR105
|
4.1
|
34.8
|
1.0
|
N
|
F:GLY106
|
4.2
|
38.9
|
1.0
|
C
|
F:THR105
|
4.3
|
38.6
|
1.0
|
C
|
F:CAS77
|
4.3
|
31.6
|
1.0
|
N
|
F:ASN78
|
4.5
|
30.9
|
1.0
|
CE
|
H:MET45
|
4.5
|
76.3
|
1.0
|
CZ
|
F:PHE148
|
4.6
|
49.4
|
1.0
|
N
|
F:CAS77
|
4.8
|
32.9
|
1.0
|
CE2
|
F:PHE148
|
4.9
|
48.8
|
1.0
|
O
|
F:PHE76
|
5.0
|
33.8
|
1.0
|
|
Arsenic binding site 7 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 7 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 7 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:As60
b:60.3
occ:1.00
|
AS
|
G:CAS60
|
0.0
|
60.3
|
1.0
|
CE1
|
G:CAS60
|
2.0
|
61.5
|
1.0
|
CE2
|
G:CAS60
|
2.0
|
61.7
|
1.0
|
SG
|
G:CAS60
|
2.2
|
54.0
|
1.0
|
CB
|
G:CAS60
|
3.1
|
49.9
|
1.0
|
CA
|
G:CAS60
|
3.3
|
48.7
|
1.0
|
N
|
G:CAS60
|
4.0
|
48.9
|
1.0
|
CD2
|
G:LEU51
|
4.0
|
50.3
|
1.0
|
NE2
|
G:GLN49
|
4.3
|
50.9
|
1.0
|
C
|
G:GLU59
|
4.5
|
51.4
|
1.0
|
C
|
G:CAS60
|
4.5
|
46.8
|
1.0
|
O
|
G:GLU59
|
4.6
|
51.2
|
1.0
|
CB
|
G:LYS55
|
4.7
|
58.7
|
1.0
|
CD
|
G:GLN49
|
4.7
|
50.6
|
1.0
|
CG
|
G:LYS55
|
4.8
|
60.5
|
1.0
|
O
|
G:CAS60
|
4.8
|
46.4
|
1.0
|
OE1
|
G:GLN49
|
4.8
|
48.9
|
1.0
|
|
Arsenic binding site 8 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 8 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 8 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
G:As89
b:85.1
occ:1.00
|
AS
|
G:CAS89
|
0.0
|
85.1
|
1.0
|
CE1
|
G:CAS89
|
2.0
|
83.4
|
1.0
|
CE2
|
G:CAS89
|
2.0
|
88.0
|
1.0
|
SG
|
G:CAS89
|
2.2
|
63.0
|
1.0
|
CB
|
G:CAS89
|
3.0
|
54.7
|
1.0
|
CA
|
G:CAS89
|
3.7
|
49.2
|
1.0
|
C
|
G:CAS89
|
4.2
|
43.9
|
1.0
|
N
|
G:ILE90
|
4.3
|
42.3
|
1.0
|
O
|
G:ILE90
|
4.7
|
41.7
|
1.0
|
O
|
G:HOH214
|
4.7
|
41.6
|
1.0
|
C
|
G:ILE90
|
4.9
|
41.7
|
1.0
|
|
Arsenic binding site 9 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 9 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 9 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
I:As77
b:44.9
occ:1.00
|
AS
|
I:CAS77
|
0.0
|
44.9
|
1.0
|
CE2
|
I:CAS77
|
2.0
|
43.6
|
1.0
|
CE1
|
I:CAS77
|
2.0
|
46.8
|
1.0
|
SG
|
I:CAS77
|
2.2
|
35.7
|
1.0
|
CB
|
I:CAS77
|
3.1
|
32.4
|
1.0
|
CA
|
I:CAS77
|
3.5
|
29.8
|
1.0
|
CA
|
I:GLY106
|
3.9
|
31.7
|
1.0
|
C
|
I:CAS77
|
4.1
|
28.9
|
1.0
|
N
|
I:GLY106
|
4.1
|
31.8
|
1.0
|
O
|
I:THR105
|
4.1
|
29.3
|
1.0
|
N
|
I:ASN78
|
4.2
|
29.1
|
1.0
|
C
|
I:THR105
|
4.2
|
31.5
|
1.0
|
N
|
I:CAS77
|
4.8
|
29.1
|
1.0
|
CE2
|
I:PHE148
|
4.9
|
42.8
|
1.0
|
O
|
I:CAS77
|
4.9
|
28.2
|
1.0
|
O
|
I:PHE76
|
5.0
|
30.7
|
1.0
|
|
Arsenic binding site 10 out
of 12 in 4w9i
Go back to
Arsenic Binding Sites List in 4w9i
Arsenic binding site 10 out
of 12 in the Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10)
Mono view
Stereo pair view
|
A full contact list of Arsenic with other atoms in the As binding
site number 10 of Pvhl:Elob:Eloc in Complex with (2S,4R)-1-((2S,4R)-1-Acetyl-4- Hydroxypyrrolidine-2-Carbonyl)-4-Hydroxy-N-(4-(4-Methylthiazol-5-Yl) Benzyl)Pyrrolidine-2-Carboxamide (Ligand 10) within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
J:As60
b:60.7
occ:1.00
|
AS
|
J:CAS60
|
0.0
|
60.7
|
1.0
|
CE2
|
J:CAS60
|
2.0
|
60.6
|
1.0
|
CE1
|
J:CAS60
|
2.0
|
59.9
|
1.0
|
SG
|
J:CAS60
|
2.3
|
46.7
|
1.0
|
CB
|
J:CAS60
|
3.2
|
39.5
|
1.0
|
CA
|
J:CAS60
|
3.4
|
37.5
|
1.0
|
N
|
J:CAS60
|
4.1
|
35.7
|
1.0
|
CD2
|
J:LEU51
|
4.1
|
36.4
|
1.0
|
O
|
J:GLU59
|
4.4
|
38.2
|
1.0
|
C
|
J:GLU59
|
4.5
|
37.9
|
1.0
|
NE2
|
J:GLN49
|
4.5
|
40.5
|
1.0
|
CB
|
J:LYS55
|
4.6
|
35.4
|
1.0
|
C
|
J:CAS60
|
4.6
|
35.4
|
1.0
|
CG
|
J:LYS55
|
4.7
|
37.3
|
1.0
|
O
|
J:CAS60
|
4.8
|
34.4
|
1.0
|
CD
|
J:GLN49
|
5.0
|
38.5
|
1.0
|
|
Reference:
C.Galdeano,
M.S.Gadd,
P.Soares,
S.Scaffidi,
I.Van Molle,
I.Birced,
S.Hewitt,
D.M.Dias,
A.Ciulli.
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction Between the Von Hippel-Lindau (Vhl) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (Hif) Alpha Subunit with in Vitro Nanomolar Affinities. J.Med.Chem. V. 57 8657 2014.
ISSN: ISSN 0022-2623
PubMed: 25166285
DOI: 10.1021/JM5011258
Page generated: Wed Jul 10 12:30:18 2024
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