Arsenic in PDB 4x0l: Human Haptoglobin-Haemoglobin Complex

The structure of Human Haptoglobin-Haemoglobin Complex, PDB code: 4x0l was solved by H.Lane-Serff, P.Macgregor, E.D.Lowe, M.Carrington, M.K.Higgins, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.93 / 2.05
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	96.599, 96.599, 132.771, 90.00, 90.00, 120.00
R / Rfree (%)	18 / 22.4

The structure of Human Haptoglobin-Haemoglobin Complex also contains other interesting chemical elements:

Iron

(Fe)

2 atoms

The binding sites of Arsenic atom in the Human Haptoglobin-Haemoglobin Complex (pdb code 4x0l). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Human Haptoglobin-Haemoglobin Complex, PDB code: 4x0l:

Arsenic binding site 1 out of 1 in the Human Haptoglobin-Haemoglobin Complex


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Human Haptoglobin-Haemoglobin Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:As505 b:0.7 occ:0.50 AS C:CAC505 0.0 0.7 0.5 O2 C:CAC505 1.7 0.6 1.0 O1 C:CAC505 1.8 47.2 0.5 C2 C:CAC505 2.0 0.4 1.0 C1 C:CAC505 2.0 0.3 1.0 OE2 C:GLU385 3.5 37.7 1.0 CA C:MET343 3.8 32.6 1.0 N C:SER344 3.8 35.2 1.0 OG C:SER344 4.2 38.1 1.0 C C:MET343 4.3 33.2 1.0 CB C:MET343 4.3 38.9 1.0 OH C:TYR386 4.6 22.8 1.0 O C:GLY342 4.6 22.8 1.0 CD C:GLU385 4.8 36.0 1.0 N C:MET343 4.9 32.7 1.0 CB C:SER344 5.0 35.0 1.0 CA C:SER344 5.0 35.9 1.0

H.Lane-Serff, P.Macgregor, E.Lowe, M.Carrington, M.Higgins. Structural Basis For Ligand and Innate Immunity Factor Uptake By the Trypanosome Haptoglobin-Haemoglobin Receptor. Elife V. 3 2014.
ISSN: ESSN 2050-084X
PubMed: 25497229
DOI: 10.7554/ELIFE.05553