Arsenic in PDB 5cb6: Structure of Adenosine-5'-Phosphosulfate Kinase

All present enzymatic activity of Structure of Adenosine-5'-Phosphosulfate Kinase:
2.7.1.25;

The structure of Structure of Adenosine-5'-Phosphosulfate Kinase, PDB code: 5cb6 was solved by J.Herrmann, J.M.Jez, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	40.34 / 2.79
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	136.904, 109.681, 100.807, 90.00, 90.72, 90.00
R / Rfree (%)	16.4 / 21.8

The structure of Structure of Adenosine-5'-Phosphosulfate Kinase also contains other interesting chemical elements:

Magnesium	(Mg)	6 atoms
Sodium	(Na)	1 atom

The binding sites of Arsenic atom in the Structure of Adenosine-5'-Phosphosulfate Kinase (pdb code 5cb6). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of Adenosine-5'-Phosphosulfate Kinase, PDB code: 5cb6:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Structure of Adenosine-5'-Phosphosulfate Kinase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Structure of Adenosine-5'-Phosphosulfate Kinase within 5.0Å range: probe atom residue distance (Å) B Occ C:As304 b:0.9 occ:1.00 AS C:CAC304 0.0 0.9 1.0 O2 C:CAC304 1.7 73.5 1.0 O1 C:CAC304 1.7 94.4 1.0 C2 C:CAC304 1.9 56.2 1.0 C1 C:CAC304 1.9 55.5 1.0 OD2 F:ASP138 4.4 61.7 1.0 OD2 C:ASP138 4.6 61.0 1.0

Arsenic binding site 2 out of 2 in the Structure of Adenosine-5'-Phosphosulfate Kinase


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Structure of Adenosine-5'-Phosphosulfate Kinase within 5.0Å range: probe atom residue distance (Å) B Occ D:As304 b:0.1 occ:1.00 AS D:CAC304 0.0 0.1 1.0 O1 D:CAC304 1.7 0.0 1.0 O2 D:CAC304 1.7 75.7 1.0 C1 D:CAC304 1.9 85.5 1.0 C2 D:CAC304 2.0 66.9 1.0 OD2 D:ASP138 4.0 70.5 1.0 OD2 E:ASP138 4.5 64.9 1.0 OD1 D:ASP138 4.8 58.0 1.0 CG D:ASP138 4.8 60.7 1.0

J.Herrmann, D.Nathin, S.G.Lee, T.Sun, J.M.Jez. Recapitulating the Structural Evolution of Redox Regulation in Adenosine 5'-Phosphosulfate Kinase From Cyanobacteria to Plants. J.Biol.Chem. V. 290 24705 2015.
ISSN: ESSN 1083-351X
PubMed: 26294763
DOI: 10.1074/JBC.M115.679514