Arsenic in PDB 5gpg: Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor

Enzymatic activity of Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor

All present enzymatic activity of Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor:
2.7.11.1; 5.2.1.8;

Protein crystallography data

The structure of Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor, PDB code: 5gpg was solved by H.B.Lee, S.Y.Lee, H.W.Rhee, C.W.Lee, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	27.73 / 1.67
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	46.038, 58.352, 86.502, 90.00, 90.00, 90.00
*R / R_free (%)*	17.4 / 21.2

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor (pdb code 5gpg). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor, PDB code: 5gpg:

Arsenic binding site 1 out of 1 in 5gpg

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Arsenic Binding Sites List in 5gpg

Arsenic binding site 1 out of 1 in the Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Co-Crystal Structure of the FK506 Binding Domain of Human FKBP25, Rapamycin and the Frb Domain of Human Mtor within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:As2085 b:23.3 occ:1.00	AS	B:CAS2085	0.0	23.3	1.0
	CE2	B:CAS2085	1.9	20.1	1.0
	CE1	B:CAS2085	1.9	16.4	1.0
	SG	B:CAS2085	2.2	18.1	1.0
	CB	B:CAS2085	3.2	17.5	1.0
	CA	B:CAS2085	3.7	12.0	1.0
	CD1	B:LEU2097	4.0	15.4	1.0
	CB	B:ALA2100	4.1	12.2	1.0
	NE1	B:TRP2101	4.3	16.0	1.0
	CE	B:MET2047	4.5	20.3	1.0
	O	B:CAS2085	4.6	14.1	1.0
	C	B:CAS2085	4.6	13.3	1.0
	CD2	B:TYR2088	4.7	17.5	1.0
	CD1	B:TRP2101	4.7	16.7	1.0
	SD	B:MET2047	4.7	14.8	1.0
	N	B:CAS2085	4.8	11.4	1.0
	CE2	B:TRP2101	5.0	12.4	1.0

Reference:

S.Y.Lee, H.Lee, H.K.Lee, S.W.Lee, S.C.Ha, T.Kwon, J.K.Seo, C.Lee, H.W.Rhee. Proximity-Directed Labeling Reveals A New Rapamycin-Induced Heterodimer of FKBP25 and Frb in Live Cells Acs Cent.Sci. V. 2 506 2016.
ISSN: ESSN 2374-7951
PubMed: 27610411
DOI: 10.1021/ACSCENTSCI.6B00137

Page generated: Wed Jul 10 12:49:58 2024

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