Arsenic in PDB 5o4e: Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6

The structure of Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6, PDB code: 5o4e was solved by G.Mlynek, E.Lobner, K.Kubinger, A.Humm, C.Obinger, K.Djinovic-Carugo, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.75 / 2.15
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	89.499, 130.345, 139.168, 90.00, 90.00, 90.00
R / Rfree (%)	20 / 23.6

The binding sites of Arsenic atom in the Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6 (pdb code 5o4e). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6, PDB code: 5o4e:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6 within 5.0Å range: probe atom residue distance (Å) B Occ A:As511 b:65.0 occ:0.38 AS A:CAC511 0.0 65.0 0.4 O2 A:CAC511 1.6 93.9 0.4 O1 A:CAC511 1.8 47.2 0.4 C1 A:CAC511 2.0 42.8 0.4 C2 A:CAC511 2.0 42.5 0.4 H11 A:CAC511 2.5 51.4 0.4 H23 A:CAC511 2.5 51.1 0.4 H12 A:CAC511 2.5 51.4 0.4 H13 A:CAC511 2.5 51.4 0.4 H21 A:CAC511 2.5 51.1 0.4 H22 A:CAC511 2.5 51.1 0.4 HD2 A:ARG344 3.8 0.6 1.0 HD3 A:ARG344 3.8 0.6 1.0 O A:GLN342 4.2 66.6 1.0 HG3 A:ARG344 4.2 91.4 1.0 CD A:ARG344 4.2 0.9 1.0 HB3 A:GLN342 4.3 0.3 1.0 HH11 A:ARG344 4.3 0.5 1.0 HB2 A:TYR373 4.6 65.7 1.0 CG A:TYR373 4.6 53.7 1.0 HB3 A:TYR373 4.6 65.7 1.0 CD1 A:TYR373 4.7 42.4 1.0 H A:GLN342 4.7 73.1 1.0 CG A:ARG344 4.8 76.2 1.0 O A:GLY402 4.8 57.1 1.0 HD1 A:TYR373 4.8 50.5 1.0 CB A:TYR373 4.8 54.7 1.0 CD2 A:TYR373 4.9 56.1 1.0 HA3 A:GLY402 5.0 59.2 1.0 O A:HOH637 5.0 63.5 1.0

Arsenic binding site 2 out of 2 in the Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Vegf in Complex with Heterodimeric Fcab JANUSCT6 within 5.0Å range: probe atom residue distance (Å) B Occ E:As203 b:64.1 occ:0.40 AS E:CAC203 0.0 64.1 0.4 O2 E:CAC203 1.6 60.9 0.4 O1 E:CAC203 1.8 59.5 0.4 C1 E:CAC203 2.0 58.6 0.4 C2 E:CAC203 2.0 67.7 0.4 H13 E:CAC203 2.5 70.3 0.4 H11 E:CAC203 2.5 70.3 0.4 H12 E:CAC203 2.5 70.3 0.4 H23 E:CAC203 2.5 81.3 0.4 H21 E:CAC203 2.5 81.3 0.4 H22 E:CAC203 2.5 81.3 0.4 NE2 E:HIS90 4.1 55.1 0.4 CE1 E:HIS90 4.2 54.6 0.4 CD2 E:HIS90 4.3 56.1 0.4 HE1 E:HIS90 4.4 65.3 0.4 ND1 E:HIS90 4.5 55.2 0.4 CG E:HIS90 4.6 57.6 0.4 HD2 E:HIS90 4.7 67.3 0.4 HD1 E:HIS90 4.9 66.3 0.4 HB3 E:HIS90 4.9 64.4 0.6

E.Lobner, A.S.Humm, G.Mlynek, K.Kubinger, M.Kitzmuller, M.W.Traxlmayr, K.Djinovic-Carugo, C.Obinger. Two-Faced Fcab Prevents Polymerization with Vegf and Reveals Thermodynamics and the 2.15 Angstrom Crystal Structure of the Complex. Mabs V. 9 1088 2017.
ISSN: ESSN 1942-0870
PubMed: 28816592
DOI: 10.1080/19420862.2017.1364825