Arsenic in PDB 5oc4: Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant

The structure of Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant, PDB code: 5oc4 was solved by C.Bou-Nader, L.Pecqueur, D.Hamdane, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	41.97 / 1.71
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	83.940, 83.940, 56.500, 90.00, 90.00, 120.00
R / Rfree (%)	19.4 / 21.5

The structure of Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Arsenic atom in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant (pdb code 5oc4). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant, PDB code: 5oc4:

Arsenic binding site 1 out of 1 in the Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Human Trna-Dihydrouridine(20) Synthase Dsrbd R361A-R362A Mutant within 5.0Å range: probe atom residue distance (Å) B Occ A:As504 b:31.8 occ:0.40 AS A:CAC504 0.0 31.8 0.4 O2 A:CAC504 1.6 29.5 0.4 O1 A:CAC504 1.7 21.5 0.4 C2 A:CAC504 2.0 32.5 0.4 C1 A:CAC504 2.0 32.5 0.4 OG1 A:THR390 3.5 26.5 1.0 NZ A:LYS419 3.8 47.1 1.0 O A:HOH618 3.8 28.2 1.0 N A:THR390 3.9 20.9 1.0 O A:HOH625 3.9 63.6 1.0 O A:HOH610 4.0 55.2 1.0 CB A:THR390 4.1 28.8 1.0 CE A:LYS419 4.5 42.2 1.0 O A:TYR388 4.6 26.9 1.0 CA A:GLU389 4.6 24.5 1.0 O A:HOH626 4.6 44.7 1.0 CA A:THR390 4.6 20.3 1.0 C A:GLU389 4.8 26.2 1.0 O A:HOH647 4.8 26.0 1.0 O A:HOH658 4.9 32.9 1.0

C.Bou-Nader, P.Barraud, L.Pecqueur, J.Perez, C.Velours, W.Shepard, M.Fontecave, C.Tisne, D.Hamdane. Molecular Basis For Transfer Rna Recognition By the Double-Stranded Rna-Binding Domain of Human Dihydrouridine Synthase 2. Nucleic Acids Res. V. 47 3117 2019.
ISSN: ESSN 1362-4962
PubMed: 30605527
DOI: 10.1093/NAR/GKY1302