Arsenic in PDB 6cxz: Rna Octamer Containing 2'-F, 4'-Calpha-Me U.

The structure of Rna Octamer Containing 2'-F, 4'-Calpha-Me U., PDB code: 6cxz was solved by J.M.Harp, M.Egli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	24.44 / 1.50
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	30.460, 30.460, 81.889, 90.00, 90.00, 90.00
R / Rfree (%)	18.6 / 21.5

The structure of Rna Octamer Containing 2'-F, 4'-Calpha-Me U. also contains other interesting chemical elements:

Fluorine	(F)	2 atoms
Cobalt	(Co)	1 atom

The binding sites of Arsenic atom in the Rna Octamer Containing 2'-F, 4'-Calpha-Me U. (pdb code 6cxz). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Rna Octamer Containing 2'-F, 4'-Calpha-Me U., PDB code: 6cxz:

Arsenic binding site 1 out of 1 in the Rna Octamer Containing 2'-F, 4'-Calpha-Me U.


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Rna Octamer Containing 2'-F, 4'-Calpha-Me U. within 5.0Å range: probe atom residue distance (Å) B Occ A:As101 b:77.0 occ:0.61 AS A:CAC101 0.0 77.0 0.6 O2 A:CAC101 1.7 43.3 0.6 O1 A:CAC101 1.7 24.5 0.6 C1 A:CAC101 2.0 15.1 0.6 C2 A:CAC101 2.0 38.7 0.6 OP1 A:U6 4.1 15.6 1.0 OP2 A:C7 4.5 18.2 1.0 H5'' A:U6 4.7 16.5 1.0 O A:HOH203 4.7 41.9 1.0 OP1 A:C7 4.7 19.1 1.0

J.M.Harp, D.C.Guenther, A.Bisbe, L.Perkins, S.Matsuda, G.R.Bommineni, I.Zlatev, D.J.Foster, N.Taneja, K.Charisse, M.A.Maier, K.G.Rajeev, M.Manoharan, M.Egli. Structural Basis For the Synergy of 4'- and 2'-Modifications on Sirna Nuclease Resistance, Thermal Stability and Rnai Activity. Nucleic Acids Res. V. 46 8090 2018.
ISSN: ESSN 1362-4962
PubMed: 30107495
DOI: 10.1093/NAR/GKY703