Arsenic in PDB 6i4x: Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide, PDB code: 6i4x was solved by W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	29.36 / 2.69
Space group	I 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	41.287, 56.327, 203.392, 90.00, 91.53, 90.00
R / Rfree (%)	19.6 / 23.5

The binding sites of Arsenic atom in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide (pdb code 6i4x). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide, PDB code: 6i4x:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:As89 b:0.8 occ:1.00 AS B:CAS89 0.0 0.8 1.0 CE2 B:CAS89 2.0 71.8 1.0 CE1 B:CAS89 2.0 75.9 1.0 SG B:CAS89 2.2 92.7 1.0 CB B:CAS89 3.1 62.2 1.0 CG B:GLU91 3.9 74.2 1.0 ND1 B:HIS10 4.0 71.0 1.0 CA B:CAS89 4.2 57.6 1.0 C B:CAS89 4.2 59.4 1.0 CD B:GLU91 4.5 80.5 1.0 O B:CAS89 4.5 46.6 1.0 CE1 B:HIS10 4.6 58.7 1.0 N B:ILE90 4.6 48.7 1.0 CA B:HIS10 4.7 45.8 1.0 N B:GLU91 4.7 47.7 1.0 CG B:HIS10 4.8 50.6 1.0 OE1 B:GLU91 4.9 89.5 1.0 OE2 B:GLU91 5.0 84.0 1.0 C B:ILE90 5.0 50.0 1.0

Arsenic binding site 2 out of 2 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Erythropoietin Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As133 b:0.7 occ:0.87 AS A:CAS133 0.0 0.7 0.9 CE2 A:CAS133 2.0 78.1 0.9 CE1 A:CAS133 2.0 67.0 0.9 SG A:CAS133 2.2 82.0 0.9 CB A:CAS133 3.1 46.5 0.9 CA A:CAS133 3.4 46.4 0.9 N A:CAS133 4.1 38.1 0.9 O A:LEU150 4.2 49.9 1.0 O A:MET132 4.3 41.2 1.0 CD1 A:TYR151 4.3 35.7 1.0 C A:MET132 4.4 41.7 1.0 C A:CAS133 4.6 57.9 0.9 O A:CAS133 4.9 67.0 0.9 CE1 A:TYR151 5.0 44.9 1.0

W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli. Structural Insights Into Substrate Recognition By the SOCS2 E3 Ubiquitin Ligase. Nat Commun V. 10 2534 2019.
ISSN: ESSN 2041-1723
PubMed: 31182716
DOI: 10.1038/S41467-019-10190-4