Arsenic in PDB 6i5j: Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5j was solved by W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.59 / 2.80
Space group	P 2 21 21
Cell size a, b, c (Å), α, β, γ (°)	57.835, 113.707, 156.944, 90.00, 90.00, 90.00
R / Rfree (%)	21 / 26.4

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide also contains other interesting chemical elements:

Cobalt

(Co)

2 atoms

The binding sites of Arsenic atom in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide (pdb code 6i5j). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 5 binding sites of Arsenic where determined in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5j:
Jump to Arsenic binding site number: 1; 2; 3; 4; 5;

Arsenic binding site 1 out of 5 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As111 b:0.1 occ:1.00 AS A:CAS111 0.0 0.1 1.0 CE2 A:CAS111 2.0 0.5 1.0 CE1 A:CAS111 2.0 0.4 1.0 SG A:CAS111 2.2 58.7 1.0 CB A:CAS111 3.1 50.8 1.0 O A:CAS111 3.9 39.1 1.0 C A:CAS111 3.9 41.1 1.0 CA A:CAS111 4.1 44.0 1.0 N A:LYS113 4.2 37.9 1.0 CA A:LYS113 4.3 38.8 1.0 NH1 A:ARG105 4.4 52.5 1.0 C A:VAL112 4.5 40.1 1.0 N A:VAL112 4.5 38.7 1.0 CB A:LYS113 4.7 40.6 1.0 N A:CAS111 4.8 38.9 1.0 CA A:VAL112 4.8 37.5 1.0 O A:VAL112 4.9 46.5 1.0

Arsenic binding site 2 out of 5 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As133 b:67.1 occ:1.00 AS A:CAS133 0.0 67.1 1.0 CE2 A:CAS133 2.0 67.7 1.0 CE1 A:CAS133 2.0 66.9 1.0 SG A:CAS133 2.2 65.6 1.0 CB A:CAS133 3.1 57.5 1.0 CE A:MET132 3.6 46.6 1.0 CA A:CAS133 3.8 50.5 1.0 O A:TYR129 3.8 31.6 1.0 N A:CAS133 4.0 41.6 1.0 O A:LEU150 4.3 46.0 1.0 CE2 K:PTR0 4.5 37.6 1.0 C A:MET132 4.6 38.3 1.0 CG A:MET132 4.8 47.0 1.0 CB A:MET132 4.8 40.4 1.0 C A:TYR129 4.8 30.0 1.0 O K:THR1 4.8 51.6 1.0 CD2 K:PTR0 4.8 34.6 1.0 CD1 K:ILE3 4.8 29.8 1.0 CD1 A:TYR129 4.8 30.0 1.0 C A:LEU150 4.8 40.1 1.0 CB A:TYR129 4.9 27.3 1.0 CA A:TYR151 4.9 39.0 1.0 O A:MET132 5.0 39.0 1.0 N A:LEU152 5.0 41.6 1.0 O K:HOH102 5.0 40.1 1.0

Arsenic binding site 3 out of 5 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:As89 b:0.5 occ:1.00 AS B:CAS89 0.0 0.5 1.0 CE2 B:CAS89 2.0 0.6 1.0 CE1 B:CAS89 2.0 0.7 1.0 SG B:CAS89 2.2 66.2 1.0 CB B:CAS89 3.1 54.3 1.0 OE1 B:GLU91 4.2 56.7 1.0 CA B:CAS89 4.3 46.2 1.0 CD2 B:HIS10 4.4 37.7 1.0 C B:CAS89 4.5 44.1 1.0 NE2 B:HIS10 4.8 37.1 1.0 N B:ILE90 4.8 42.6 1.0 CG B:HIS10 4.8 37.0 1.0 O B:CAS89 4.8 44.6 1.0

Arsenic binding site 4 out of 5 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ D:As133 b:87.0 occ:1.00 AS D:CAS133 0.0 87.0 1.0 CE1 D:CAS133 2.0 87.1 1.0 CE2 D:CAS133 2.0 84.3 1.0 SG D:CAS133 2.2 65.8 1.0 CB D:CAS133 3.1 58.2 1.0 O D:TYR129 3.4 48.4 1.0 CA D:CAS133 3.7 54.6 1.0 N D:CAS133 3.9 50.2 1.0 CE D:MET132 4.2 59.2 1.0 O D:LEU150 4.3 64.1 1.0 C D:MET132 4.4 51.2 1.0 C D:TYR129 4.5 45.0 1.0 CB D:MET132 4.6 54.1 1.0 CG D:MET132 4.7 59.8 1.0 N D:LEU152 4.7 46.1 1.0 CA D:TYR151 4.7 53.1 1.0 CE2 L:PTR0 4.7 80.9 1.0 O D:MET132 4.8 54.6 1.0 CB D:TYR129 4.8 46.7 1.0 C D:LEU150 4.8 60.1 1.0 CA D:TYR129 4.9 44.7 1.0 CD1 D:TYR129 4.9 48.9 1.0 N D:TYR151 5.0 54.8 1.0 CD2 L:PTR0 5.0 80.7 1.0

Arsenic binding site 5 out of 5 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 5 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ E:As89 b:89.5 occ:1.00 AS E:CAS89 0.0 89.5 1.0 CE2 E:CAS89 2.0 90.9 1.0 CE1 E:CAS89 2.0 86.1 1.0 SG E:CAS89 2.2 59.5 1.0 CB E:CAS89 3.1 45.5 1.0 CA E:CAS89 3.7 34.1 1.0 C E:CAS89 4.3 31.4 1.0 N E:ILE90 4.3 32.7 1.0 O E:LEU88 4.9 39.3 1.0 O E:ILE90 5.0 39.1 1.0 N E:CAS89 5.0 28.2 1.0

W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli. Structural Insights Into Substrate Recognition By the SOCS2 E3 Ubiquitin Ligase. Nat Commun V. 10 2534 2019.
ISSN: ESSN 2041-1723
PubMed: 31182716
DOI: 10.1038/S41467-019-10190-4