Arsenic in PDB 6i5n: Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5n was solved by W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.04 / 1.98
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	113.177, 156.763, 57.571, 90.00, 90.00, 90.00
R / Rfree (%)	19 / 22.6

The structure of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide also contains other interesting chemical elements:

Cobalt

(Co)

2 atoms

The binding sites of Arsenic atom in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide (pdb code 6i5n). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 7 binding sites of Arsenic where determined in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide, PDB code: 6i5n:
Jump to Arsenic binding site number: 1; 2; 3; 4; 5; 6; 7;

Arsenic binding site 1 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As111 b:66.1 occ:0.87 AS A:CAS111 0.0 66.1 0.9 CE2 A:CAS111 2.0 63.8 0.9 CE1 A:CAS111 2.0 62.0 0.9 SG A:CAS111 2.3 36.1 0.9 CB A:CAS111 3.1 28.7 0.9 C A:CAS111 3.8 22.6 0.9 N A:LYS113 3.9 31.4 1.0 O A:CAS111 4.0 22.9 0.9 CA A:CAS111 4.0 21.9 0.9 CA A:LYS113 4.1 33.5 1.0 C A:VAL112 4.1 29.0 1.0 N A:VAL112 4.1 28.3 1.0 O A:VAL112 4.5 26.0 1.0 CA A:VAL112 4.5 28.1 1.0 O A:HOH340 4.6 27.7 1.0 CB A:LYS113 4.7 38.4 1.0 N A:CAS111 4.8 21.6 0.9

Arsenic binding site 2 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As133 b:36.5 occ:0.92 AS A:CAS133 0.0 36.5 0.9 CE2 A:CAS133 2.0 35.8 0.9 CE1 A:CAS133 2.0 35.1 0.9 SG A:CAS133 2.2 32.2 0.9 CB A:CAS133 3.2 27.1 0.9 O A:TYR129 3.4 24.1 1.0 CA A:CAS133 3.6 28.6 0.9 N A:CAS133 3.7 27.1 0.9 SD A:MET132 3.8 31.0 1.0 CG A:MET132 4.0 31.6 1.0 CB A:MET132 4.1 27.4 1.0 C A:MET132 4.2 30.1 1.0 C A:TYR129 4.4 21.9 1.0 CD1 A:TYR129 4.5 26.8 1.0 O A:LEU150 4.5 25.9 1.0 CE2 K:PTR0 4.5 38.8 1.0 CB A:TYR129 4.6 21.1 1.0 CA A:TYR129 4.6 20.2 1.0 CD2 K:PTR0 4.7 39.3 1.0 O A:MET132 4.8 32.2 1.0 CA A:MET132 4.8 29.6 1.0 CD1 K:ILE3 4.9 27.9 1.0

Arsenic binding site 3 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:As174 b:69.0 occ:0.87 AS A:CAS174 0.0 69.0 0.9 CE2 A:CAS174 2.0 67.0 0.9 CE1 A:CAS174 2.0 69.9 0.9 SG A:CAS174 2.3 43.0 0.9 CB A:CAS174 3.2 34.0 0.9 O C:PRO97 4.3 23.5 1.0 CA B:MET103 4.5 0.4 1.0 CB B:MET103 4.6 0.7 1.0 CA A:CAS174 4.6 29.2 0.9 CA A:ILE171 4.6 19.1 1.0 CG2 A:THR175 4.8 23.6 1.0 CD2 B:LEU99 4.8 84.6 1.0 O A:ILE171 4.8 19.7 1.0 CG1 A:ILE171 4.8 17.6 1.0 CB C:PRO97 4.8 29.0 1.0 CG2 A:ILE171 4.9 16.3 1.0 O C:HOH238 4.9 23.4 1.0 C A:CAS174 5.0 27.3 0.9

Arsenic binding site 4 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ B:As89 b:76.1 occ:1.00 AS B:CAS89 0.0 76.1 1.0 CE1 B:CAS89 2.0 77.0 1.0 CE2 B:CAS89 2.0 79.4 1.0 SG B:CAS89 2.2 55.3 1.0 CB B:CAS89 2.8 44.7 1.0 C B:CAS89 3.7 33.0 1.0 CA B:CAS89 3.8 35.9 1.0 O B:CAS89 3.9 32.4 1.0 CD2 B:HIS10 4.1 34.7 1.0 N B:ILE90 4.2 33.2 1.0 CA B:HIS10 4.3 30.1 1.0 CG B:HIS10 4.3 34.8 1.0 N B:GLU91 4.4 32.2 1.0 C B:ILE90 4.6 32.7 1.0 NE2 B:HIS10 4.6 38.0 1.0 OE1 B:GLU91 4.6 48.2 1.0 CB B:HIS10 4.7 25.5 1.0 CA B:ILE90 4.7 29.3 1.0 CA B:GLU91 4.9 33.6 1.0 ND1 B:HIS10 4.9 36.1 1.0 N B:HIS10 4.9 23.0 1.0 CB B:GLU91 5.0 35.6 1.0

Arsenic binding site 5 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 5 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ D:As133 b:64.3 occ:1.00 AS D:CAS133 0.0 64.3 1.0 CE2 D:CAS133 2.0 58.8 1.0 CE1 D:CAS133 2.0 66.8 1.0 SG D:CAS133 2.2 54.5 1.0 CB D:CAS133 3.2 46.5 1.0 O D:TYR129 3.4 36.7 1.0 N D:CAS133 3.6 47.0 1.0 CA D:CAS133 3.7 53.3 1.0 SD D:MET132 3.7 52.5 1.0 CG D:MET132 4.0 51.1 1.0 O D:LEU150 4.1 55.3 1.0 C D:MET132 4.2 48.4 1.0 CB D:MET132 4.3 48.2 1.0 C D:TYR129 4.4 32.1 1.0 CE2 L:PTR0 4.5 81.0 0.9 CD2 L:PTR0 4.6 81.6 0.9 CD1 D:TYR129 4.6 42.1 1.0 O D:MET132 4.7 52.1 1.0 CB D:TYR129 4.7 34.5 1.0 CA D:TYR129 4.7 29.9 1.0 CA D:MET132 4.8 50.7 1.0 C D:LEU150 4.9 54.2 1.0

Arsenic binding site 6 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 6 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ D:As174 b:55.9 occ:0.86 AS D:CAS174 0.0 55.9 0.9 CE2 D:CAS174 2.0 56.6 0.9 CE1 D:CAS174 2.0 48.9 0.9 SG D:CAS174 2.3 39.5 0.9 CB D:CAS174 3.2 31.5 0.9 O F:PRO97 4.0 21.8 1.0 CB F:PRO97 4.5 26.8 1.0 CA D:CAS174 4.6 19.5 0.9 CA F:PRO97 4.6 23.9 1.0 C F:PRO97 4.6 22.2 1.0 O F:HOH228 4.8 27.3 1.0 CA D:ILE171 4.8 14.3 1.0 CD2 F:LEU101 4.9 27.0 1.0 CG2 D:THR175 4.9 20.8 1.0 CG1 D:ILE171 5.0 15.6 1.0 O D:ILE171 5.0 18.7 1.0

Arsenic binding site 7 out of 7 in the Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 7 of Crystal Structure of SOCS2:Elongin C:Elongin B in Complex with Growth Hormone Receptor Peptide within 5.0Å range: probe atom residue distance (Å) B Occ E:As89 b:29.6 occ:0.93 AS E:CAS89 0.0 29.6 0.9 CE2 E:CAS89 2.0 38.0 0.9 CE1 E:CAS89 2.0 31.2 0.9 SG E:CAS89 2.3 24.0 0.9 CB E:CAS89 3.2 20.9 0.9 CA E:CAS89 3.6 19.8 0.9 O E:HOH236 4.0 24.3 1.0 O E:HOH248 4.1 21.5 0.5 N E:ILE90 4.1 18.9 1.0 C E:CAS89 4.2 18.6 0.9 O E:ILE90 4.5 20.5 1.0 O E:LEU88 4.7 21.6 1.0 O E:HOH234 4.7 22.6 1.0 C E:ILE90 4.8 22.9 1.0 N E:CAS89 4.9 18.9 0.9

W.W.Kung, S.Ramachandran, N.Makukhin, E.Bruno, A.Ciulli. Structural Insights Into Substrate Recognition By the SOCS2 E3 Ubiquitin Ligase. Nat Commun V. 10 2534 2019.
ISSN: ESSN 2041-1723
PubMed: 31182716
DOI: 10.1038/S41467-019-10190-4