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Atomistry » Arsenic » PDB 6j05-6wrb » 6lmi » |
Arsenic in PDB 6lmi: Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic AcidProtein crystallography data
The structure of Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic Acid, PDB code: 6lmi
was solved by
S.Sugiyama,
T.Iwaki,
Y.Tamura,
K.Tomita,
E.Matsuoka,
S.Arita,
T.Seki,
T.Yoshinaga,
T.Kawasuji,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Arsenic Binding Sites:
The binding sites of Arsenic atom in the Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic Acid
(pdb code 6lmi). This binding sites where shown within
5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic Acid, PDB code: 6lmi: Jump to Arsenic binding site number: 1; 2; Arsenic binding site 1 out of 2 in 6lmiGo back to Arsenic Binding Sites List in 6lmi
Arsenic binding site 1 out
of 2 in the Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic Acid
Mono view Stereo pair view
Arsenic binding site 2 out of 2 in 6lmiGo back to Arsenic Binding Sites List in 6lmi
Arsenic binding site 2 out
of 2 in the Crystal Structure of Hiv-1 Integrase Catalytic Core Domain in Complex with 2-(Tert-Butoxy)-2-[3-(3,4-Dihydro-2H-1-Benzopyran-6-Yl)-6- Methanesulfonamido-2,3',4',5-Tetramethyl-[1,1'-Biphenyl]-4-Yl]Acetic Acid
Mono view Stereo pair view
Reference:
S.Sugiyama,
T.Iwaki,
Y.Tamura,
K.Tomita,
E.Matsuoka,
S.Arita,
T.Seki,
T.Yoshinaga,
T.Kawasuji.
Discovery of Novel Integrase-Ledgf/P75 Allosteric Inhibitors Based on A Benzene Scaffold. Bioorg.Med.Chem. V. 28 15643 2020.
Page generated: Wed Jul 10 13:27:44 2024
ISSN: ESSN 1464-3391 PubMed: 32773094 DOI: 10.1016/J.BMC.2020.115643 |
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