Atomistry » Arsenic » PDB 6xna-7ji7 » 7eds
Atomistry »
  Arsenic »
    PDB 6xna-7ji7 »
      7eds »

Arsenic in PDB 7eds: Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic

Protein crystallography data

The structure of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic, PDB code: 7eds was solved by Y.F.Xing, M.Lu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.88 / 1.77
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 137.53, 49.88, 33.95, 90, 93.31, 90
R / Rfree (%) 21 / 22.7

Other elements in 7eds:

The structure of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic (pdb code 7eds). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic, PDB code: 7eds:

Arsenic binding site 1 out of 1 in 7eds

Go back to Arsenic Binding Sites List in 7eds
Arsenic binding site 1 out of 1 in the Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Human P53 Core Domain with Germline Hot Spot Mutation M133T in Complex with the Natural PIG3 P53-Response Element and Arsenic within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As301

b:43.8
occ:0.60
SG A:CYS124 2.2 41.6 1.0
SG A:CYS135 2.2 37.3 1.0
SG A:CYS141 2.2 41.1 1.0
CB A:CYS141 3.1 28.6 1.0
CB A:CYS124 3.2 32.9 1.0
CB A:CYS135 3.2 20.3 1.0
CA A:CYS135 3.7 17.2 1.0
CA A:CYS141 3.7 22.1 1.0
O A:PHE134 3.9 14.1 1.0
CA A:CYS124 3.9 24.3 1.0
CB A:THR133 4.1 16.6 1.0
N A:CYS135 4.2 14.7 1.0
C A:PHE134 4.3 13.5 1.0
OG1 A:THR133 4.5 19.9 1.0
O A:THR140 4.5 17.8 1.0
N A:CYS141 4.7 17.2 1.0
C A:CYS124 4.7 21.4 1.0
N A:THR125 4.7 18.0 1.0
CG2 A:THR133 4.7 16.5 1.0
O A:THR123 4.8 21.6 1.0
N A:PHE134 4.8 13.6 1.0
C A:CYS141 4.9 18.6 1.0

Reference:

Y.F.Xing, M.Lu. Arsenic-Bound P53 Hotspot Mutant M133T in Complex with the Natural PIG3 P53-Response Element To Be Published.
Page generated: Wed Jul 10 13:41:50 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy