Arsenic in PDB 7m6t: Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding

The structure of Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding, PDB code: 7m6t was solved by N.J.Kershaw, K.Li, E.M.Linossi, S.E.Nicholson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.38 / 3.19
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	60.749, 110.612, 139.896, 90, 90, 90
R / Rfree (%)	22.7 / 26.7

The binding sites of Arsenic atom in the Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding (pdb code 7m6t). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding, PDB code: 7m6t:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding within 5.0Å range: probe atom residue distance (Å) B Occ A:As111 b:136.9 occ:1.00 AS A:CAS111 0.0 136.9 1.0 CE2 A:CAS111 2.0 115.6 1.0 CE1 A:CAS111 2.0 121.3 1.0 SG A:CAS111 2.2 144.6 1.0 CB A:CAS111 3.0 127.4 1.0 CA A:CAS111 3.8 127.3 1.0 N A:CAS111 4.5 118.4 1.0 CE1 A:HIS149 4.6 130.2 1.0 CG2 A:ILE110 4.7 118.9 1.0 CD1 A:LEU106 4.8 106.3 1.0 O A:ILE110 4.9 114.5 1.0 C A:ILE110 5.0 117.8 1.0

Arsenic binding site 2 out of 2 in the Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of SOCS2/Elonginb/Elonginc Bound to A Non-Canonical Peptide That Enhances Phospho-Peptide Binding within 5.0Å range: probe atom residue distance (Å) B Occ B:As89 b:218.7 occ:1.00 AS B:CAS89 0.0 218.7 1.0 CE1 B:CAS89 2.0 159.0 1.0 CE2 B:CAS89 2.0 169.7 1.0 SG B:CAS89 2.2 191.9 1.0 CB B:CAS89 3.1 151.8 1.0 ND1 B:HIS10 3.5 142.9 1.0 C B:CAS89 4.0 141.5 1.0 CE1 B:HIS10 4.1 145.8 1.0 CA B:CAS89 4.1 145.9 1.0 N B:ILE90 4.3 142.9 1.0 O B:CAS89 4.3 135.7 1.0 N B:GLU91 4.4 128.4 1.0 CG B:HIS10 4.4 142.9 1.0 CA B:HIS10 4.4 130.8 1.0 C B:ILE90 4.5 135.3 1.0 CB B:GLU91 4.7 132.3 1.0 OE1 B:GLU91 4.8 141.2 1.0 CA B:ILE90 4.8 140.8 1.0 CA B:GLU91 4.8 128.6 1.0 CB B:HIS10 4.8 135.2 1.0 O B:ILE90 5.0 130.9 1.0

E.M.Linossi, K.Li, G.Veggiani, C.Tan, F.Dehkhoda, C.Hockings, D.Calleja, N.Keating, R.Feltham, A.J.Brooks, S.S.Li, S.S.Sidhu, J.J.Babon, N.J.Kershaw, S.E.Nicholson. Identification of A Novel Exosite on the SOCS2-SH2 Domain That Enhances Its Binding to Phosphorylated Ligands To Be Published.