Arsenic in PDB 7sxp: G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution

The structure of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution, PDB code: 7sxp was solved by M.T.Banco, A.R.Ferre-D'amare, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	31.53 / 2.90
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	36.402, 36.402, 70.103, 90, 90, 120
R / Rfree (%)	24.1 / 27.7

The structure of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution also contains other interesting chemical elements:

Potassium

(K)

3 atoms

The binding sites of Arsenic atom in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution (pdb code 7sxp). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution, PDB code: 7sxp:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution within 5.0Å range: probe atom residue distance (Å) B Occ A:As104 b:150.7 occ:1.00 AS A:CAD104 0.0 150.7 1.0 O1 A:CAD104 1.8 97.9 1.0 O2 A:CAD104 1.8 88.3 1.0 C2 A:CAD104 2.0 91.7 1.0 C1 A:CAD104 2.0 106.2 1.0 N2 A:G4 4.1 69.7 1.0 O4' A:G5 4.2 73.3 1.0 N3 A:G4 4.6 66.2 1.0 C1' A:G5 4.7 70.0 1.0 O2' A:G4 4.7 91.3 1.0 OP2 A:G9 4.8 105.7 1.0 C2 A:G4 4.8 63.2 1.0

Arsenic binding site 2 out of 2 in the G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of G-Quadruplex Structure Formed in the Nras Mrna with A G8U Substitution within 5.0Å range: probe atom residue distance (Å) B Occ A:As105 b:163.4 occ:1.00 AS A:CAD105 0.0 163.4 1.0 O2 A:CAD105 1.8 107.9 1.0 O1 A:CAD105 1.8 112.2 1.0 C1 A:CAD105 2.0 90.9 1.0 C2 A:CAD105 2.0 120.0 1.0 O4' A:G14 4.9 80.8 1.0

S.Balaratnam, Z.Torrey, D.R.Calabrese, M.T.Banco, K.Yazdani, X.Liang, A.R.Ferre-D'amare, D.Incarnato, J.S.Schneekloth Jr. Investigating the Nras 5' Utr As A Target For Small Molecules To Be Published.