Arsenic in PDB 7tp3: Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2

The structure of Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2, PDB code: 7tp3 was solved by M.Yuan, X.Zhu, I.A.Wilson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.50 / 2.33
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	72.462, 88.553, 131.495, 90, 90, 90
R / Rfree (%)	18.5 / 23.1

The binding sites of Arsenic atom in the Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2 (pdb code 7tp3). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 3 binding sites of Arsenic where determined in the Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2, PDB code: 7tp3:
Jump to Arsenic binding site number: 1; 2; 3;

Arsenic binding site 1 out of 3 in the Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2 within 5.0Å range: probe atom residue distance (Å) B Occ Z:As601 b:207.4 occ:1.00 AS Z:CAC601 0.0 207.4 1.0 O2 Z:CAC601 1.7 130.8 1.0 O1 Z:CAC601 1.7 72.6 1.0 C2 Z:CAC601 2.0 116.8 1.0 C1 Z:CAC601 2.0 105.8 1.0 ND2 Z:ASN354 4.1 75.8 1.0

Arsenic binding site 2 out of 3 in the Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2 within 5.0Å range: probe atom residue distance (Å) B Occ L:As301 b:191.5 occ:1.00 AS L:CAC301 0.0 191.5 1.0 O1 L:CAC301 1.7 92.8 1.0 O2 L:CAC301 1.7 118.5 1.0 C1 L:CAC301 2.0 104.0 1.0 C2 L:CAC301 2.0 97.2 1.0 O L:ASP9 4.0 48.8 1.0 O L:GLY101 4.3 45.5 1.0 C L:GLY101 4.7 54.6 1.0 CB L:ASP9 4.8 59.7 1.0 O L:GLY100 4.8 47.2 1.0 C L:ASP9 4.8 50.9 1.0 N L:LYS103 4.9 47.5 1.0 CB L:LYS103 5.0 39.7 1.0 CA L:ASP9 5.0 49.9 1.0

Arsenic binding site 3 out of 3 in the Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Crystal Structure of Sars-Cov-2 Receptor Binding Domain in Complex with Neutralizing Antibody K288.2 within 5.0Å range: probe atom residue distance (Å) B Occ L:As302 b:211.2 occ:1.00 AS L:CAC302 0.0 211.2 1.0 O1 L:CAC302 1.7 130.9 1.0 O2 L:CAC302 1.7 170.1 1.0 C1 L:CAC302 2.0 114.7 1.0 C2 L:CAC302 2.0 106.0 1.0 OD2 L:ASP81 4.4 92.1 1.0 CD L:PRO59 4.4 74.4 1.0 CG L:PRO59 4.6 79.3 1.0 SD L:MET58 4.8 111.0 1.0 CD L:ARG45 5.0 83.8 1.0

W.T.He, M.Yuan, S.Callaghan, R.Musharrafieh, G.Song, M.Silva, N.Beutler, W.H.Lee, P.Yong, J.L.Torres, M.Melo, P.Zhou, F.Zhao, X.Zhu, L.Peng, D.Huang, F.Anzanello, J.Ricketts, M.Parren, E.Garcia, M.Ferguson, W.Rinaldi, S.A.Rawlings, D.Nemazee, D.M.Smith, B.Briney, Y.Safonova, T.F.Rogers, J.M.Dan, Z.Zhang, D.Weiskopf, A.Sette, S.Crotty, D.J.Irvine, A.B.Ward, I.A.Wilson, D.R.Burton, R.Andrabi. Broadly Neutralizing Antibodies to Sars-Related Viruses Can Be Readily Induced in Rhesus Macaques. Sci Transl Med V. 14 L9605 2022.
ISSN: ESSN 1946-6242
PubMed: 35947674
DOI: 10.1126/SCITRANSLMED.ABL9605