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Arsenic in PDB 7xbm: Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

Enzymatic activity of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

All present enzymatic activity of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238:
1.14.15.33;

Protein crystallography data

The structure of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238, PDB code: 7xbm was solved by G.B.Li, Y.J.Pan, S.Y.Li, X.Gao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.51 / 2.40
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 60.04, 108.331, 153.3, 90, 90, 90
R / Rfree (%) 18.4 / 23

Other elements in 7xbm:

The structure of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 also contains other interesting chemical elements:

Iron (Fe) 2 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 (pdb code 7xbm). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238, PDB code: 7xbm:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 7xbm

Go back to Arsenic Binding Sites List in 7xbm
Arsenic binding site 1 out of 2 in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As503

b:158.9
occ:1.00
 AS A:CAC503 0.0 158.9 1.0
O1 A:CAC503 1.6 113.9 1.0
O2 A:CAC503 1.8 115.6 1.0
C1 A:CAC503 2.0 59.1 1.0
C2 A:CAC503 2.0 72.8 1.0
O A:HOH619 3.9 55.7 1.0
OD2 A:ASP167 4.2 47.7 1.0
CE1 A:TYR197 4.6 31.8 1.0

Arsenic binding site 2 out of 2 in 7xbm

Go back to Arsenic Binding Sites List in 7xbm
Arsenic binding site 2 out of 2 in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As506

b:155.3
occ:1.00
 AS B:CAC506 0.0 155.3 1.0
O1 B:CAC506 1.6 109.7 1.0
O2 B:CAC506 1.8 62.5 1.0
C1 B:CAC506 2.0 103.3 1.0
C2 B:CAC506 2.0 51.6 1.0
OD2 B:ASP167 4.0 44.3 1.0
O B:HOH697 4.2 59.5 1.0
CE1 B:TYR197 4.5 39.9 1.0
CG B:ASP167 4.8 46.7 1.0
OD1 B:ASP167 5.0 48.2 1.0

Reference:

Y.J.Pan, G.B.Li, X.Gao, S.Y.Li. Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 Nat Commun 2023.
ISSN: ESSN 2041-1723
Page generated: Wed Jul 10 13:52:55 2024

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