Arsenic in PDB 7xbm: Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

Enzymatic activity of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

All present enzymatic activity of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238:
1.14.15.33;

Protein crystallography data

The structure of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238, PDB code: 7xbm was solved by G.B.Li, Y.J.Pan, S.Y.Li, X.Gao, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	23.51 / 2.40
*Space group*	P 2₁ 2₁ 2₁
*Cell size a, b, c (Å), α, β, γ (°)*	60.04, 108.331, 153.3, 90, 90, 90
*R / R_free (%)*	18.4 / 23

Other elements in 7xbm:

The structure of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 also contains other interesting chemical elements:

Iron

(Fe)

2 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 (pdb code 7xbm). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238, PDB code: 7xbm:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 7xbm

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Arsenic Binding Sites List in 7xbm

Arsenic binding site 1 out of 2 in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As503 b:158.9 occ:1.00	AS	A:CAC503	0.0	158.9	1.0
	O1	A:CAC503	1.6	113.9	1.0
	O2	A:CAC503	1.8	115.6	1.0
	C1	A:CAC503	2.0	59.1	1.0
	C2	A:CAC503	2.0	72.8	1.0
	O	A:HOH619	3.9	55.7	1.0
	OD2	A:ASP167	4.2	47.7	1.0
	CE1	A:TYR197	4.6	31.8	1.0

Arsenic binding site 2 out of 2 in 7xbm

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Arsenic Binding Sites List in 7xbm

Arsenic binding site 2 out of 2 in the Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
B:As506 b:155.3 occ:1.00	AS	B:CAC506	0.0	155.3	1.0
	O1	B:CAC506	1.6	109.7	1.0
	O2	B:CAC506	1.8	62.5	1.0
	C1	B:CAC506	2.0	103.3	1.0
	C2	B:CAC506	2.0	51.6	1.0
	OD2	B:ASP167	4.0	44.3	1.0
	O	B:HOH697	4.2	59.5	1.0
	CE1	B:TYR197	4.5	39.9	1.0
	CG	B:ASP167	4.8	46.7	1.0
	OD1	B:ASP167	5.0	48.2	1.0

Reference:

Y.J.Pan, G.B.Li, X.Gao, S.Y.Li. Crystal Structure of Cytochrome P450 Pikc with the Unnatural Amino Acid P-Acetyl-L-Phenylalanine Incorporated at Position 238 Nat Commun 2023.
ISSN: ESSN 2041-1723

Page generated: Mon Jul 7 01:04:16 2025

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