Arsenic in PDB 8cyf: WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna

All present enzymatic activity of WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna:
2.7.7.6;

The structure of WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna, PDB code: 8cyf was solved by T.Wan, L.M.Zhang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.15 / 2.44
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	50.697, 72.934, 95.38, 90, 90, 90
R / Rfree (%)	22.2 / 25.1

The structure of WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna also contains other interesting chemical elements:

Iron

(Fe)

4 atoms

The binding sites of Arsenic atom in the WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna (pdb code 8cyf). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna, PDB code: 8cyf:

Arsenic binding site 1 out of 1 in the WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of WHIB3 Bound to SIGMAAR4-Rnap Beta Flap Tip Chimera and Dna within 5.0Å range: probe atom residue distance (Å) B Occ B:As601 b:148.4 occ:0.88 AS B:CAC601 0.0 148.4 0.9 O1 B:CAC601 1.7 116.0 0.9 O2 B:CAC601 1.8 107.8 0.9 C2 B:CAC601 2.0 122.8 0.9 C1 B:CAC601 2.0 116.0 0.9 O B:GLY497 3.2 64.3 1.0 C B:GLY497 4.3 59.8 1.0 CA B:GLY497 4.7 59.0 1.0 OP1 D:DT14 4.8 53.5 1.0

T.Wan, M.Horova, V.Khetrapal, S.Li, C.Jones, A.Schacht, X.Sun, L.Zhang. Structural Basis of Dna Binding By the Whib-Like Transcription Factor WHIB3 in Mycobacterium Tuberculosis. J.Biol.Chem. 04777 2023.
ISSN: ESSN 1083-351X
PubMed: 37142222
DOI: 10.1016/J.JBC.2023.104777