Arsenic in PDB 8egw: Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3)

The structure of Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3), PDB code: 8egw was solved by E.Medina, V.C.Luca, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.08 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	88.66, 61.37, 100.966, 90, 112.74, 90
R / Rfree (%)	19 / 23.5

The structure of Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3) also contains other interesting chemical elements:

Calcium

(Ca)

19 atoms

The binding sites of Arsenic atom in the Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3) (pdb code 8egw). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 3 binding sites of Arsenic where determined in the Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3), PDB code: 8egw:
Jump to Arsenic binding site number: 1; 2; 3;

Arsenic binding site 1 out of 3 in the Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3) within 5.0Å range: probe atom residue distance (Å) B Occ A:As410 b:189.0 occ:1.00 AS A:CAC410 0.0 189.0 1.0 O1 A:CAC410 1.7 190.0 1.0 O2 A:CAC410 1.7 187.7 1.0 C2 A:CAC410 2.0 183.3 1.0 C1 A:CAC410 2.0 185.6 1.0 O A:HOH556 3.7 63.4 1.0 NE2 B:GLN153 3.9 78.7 1.0 O A:SER345 4.0 41.2 1.0 O A:HOH515 4.4 68.6 1.0 CB A:SER258 4.7 54.7 1.0 CE2 A:PHE347 4.8 36.9 1.0 OG A:SER345 4.8 64.0 1.0 O A:SER258 4.8 52.8 1.0 C A:SER345 4.9 40.2 1.0 O A:HOH552 4.9 42.4 1.0 CD B:GLN153 5.0 75.2 1.0

Arsenic binding site 2 out of 3 in the Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3) within 5.0Å range: probe atom residue distance (Å) B Occ A:As412 b:196.7 occ:1.00 AS A:CAC412 0.0 196.7 1.0 O1 A:CAC412 1.7 195.5 1.0 O2 A:CAC412 1.7 195.3 1.0 C1 A:CAC412 2.0 198.8 1.0 C2 A:CAC412 2.0 194.0 1.0 OE1 A:GLU317 3.1 84.5 1.0 CD A:GLU317 4.1 76.4 1.0 OE2 A:GLU317 4.4 77.3 1.0 O A:HOH567 4.8 65.9 1.0 OE1 A:GLN315 4.9 61.4 1.0

Arsenic binding site 3 out of 3 in the Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Complex of FAT4(EC1-4) Bound to DCHS1(EC1-3) within 5.0Å range: probe atom residue distance (Å) B Occ A:As414 b:197.9 occ:1.00 AS A:CAC414 0.0 197.9 1.0 O2 A:CAC414 1.7 196.5 1.0 O1 A:CAC414 1.7 195.3 1.0 C2 A:CAC414 2.0 192.3 1.0 C1 A:CAC414 2.0 195.0 1.0 OE1 A:GLN178 4.2 70.5 1.0 O A:GLY201 4.3 93.3 1.0 O A:GLY173 4.4 70.6 1.0 C A:GLY173 4.6 64.4 1.0 C A:GLY201 4.7 105.5 1.0 O A:ASP200 4.8 130.9 1.0 CA A:GLY173 4.8 54.9 1.0 NE2 A:GLN178 4.8 56.1 1.0 CD A:GLN178 4.9 69.3 1.0

E.Medina, Y.Easa, D.Sprinzak, V.C.Luca. Structural Basis For Interactions Between the Planar Cell Polarity Cadherins FAT4 and DACHSOUS1 To Be Published.