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Arsenic in PDB 8jbp: Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57

Enzymatic activity of Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57

All present enzymatic activity of Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57:
5.3.1.1;

Protein crystallography data

The structure of Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57, PDB code: 8jbp was solved by B.Kuaprasert, U.Leartsakulpanich, P.Riangrungroj, W.Pornthanakasem, W.Suginta, R.C.Robinson, Y.Zhou, M.Mungthin, S.Leelayoova, S.Saehlee, K.Choowongkomon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.74 / 1.45
Space group P 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 39.7, 79.353, 83.114, 90, 101.24, 90
R / Rfree (%) 16.2 / 19

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57 (pdb code 8jbp). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57, PDB code: 8jbp:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in 8jbp

Go back to Arsenic Binding Sites List in 8jbp
Arsenic binding site 1 out of 2 in the Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:As301

b:36.1
occ:1.00
 SG A:CYS57 2.3 21.1 1.0
CB A:CYS57 3.3 21.5 1.0
O A:CYS57 3.9 29.0 1.0
C A:CYS57 4.2 19.7 1.0
CA A:CYS57 4.4 17.2 1.0
O A:ASN30 4.8 20.7 1.0
CB A:ASN30 4.9 14.9 1.0
N A:ASN58 5.0 17.3 1.0

Arsenic binding site 2 out of 2 in 8jbp

Go back to Arsenic Binding Sites List in 8jbp
Arsenic binding site 2 out of 2 in the Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Triosephosphate Isomerase From Leishmania Orientalis at 1.45 Angstroms Resolution with An Arsenic Atom Bound at CYS57 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As301

b:29.1
occ:1.00
 SG B:CYS57 2.2 19.3 1.0
CB B:CYS57 3.2 17.1 1.0
N A:TRP194 3.8 11.9 1.0
C A:GLN193 3.9 13.6 1.0
CA A:TRP194 3.9 12.0 1.0
CB A:GLN193 4.1 15.4 1.0
O A:GLN193 4.1 13.1 1.0
OE2 A:GLU197 4.3 31.0 1.0
CB A:TRP194 4.3 13.5 1.0
CA B:CYS57 4.5 15.0 1.0
CD A:GLU197 4.6 26.9 1.0
CA A:GLN193 4.7 15.1 1.0
N B:CYS57 4.7 14.1 1.0
O B:LYS55 4.7 15.1 1.0
ND2 B:ASN30 4.7 12.1 1.0
O A:LEU190 4.7 14.2 1.0
CG A:GLU197 4.9 20.1 1.0
OE1 A:GLN193 4.9 36.7 1.0
CD1 A:TRP194 4.9 13.7 1.0
O A:HOH582 5.0 33.5 1.0

Reference:

B.Kuaprasert, U.Leartsakulpanich, P.Riangrungroj, W.Pornthanakasem, W.Suginta, C.R.Robinson, Y.Zhou, M.Mungthin, S.Leelayoova, S.Saehlee, D.Kiriwan, K.Choowongkomon. Leishmania Orientalis Triosephosphate Isomerase Crystal Structure at 1.45 Angstroms Resolution and Its Potential Specific Inhibitors To Be Published.
Page generated: Wed Jul 10 14:02:51 2024

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