Arsenic in PDB 8pxu: Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood

The structure of Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood, PDB code: 8pxu was solved by M.Jensen, M.Abou Hachem, J.P.Morth, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.40 / 1.99
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	96.707, 170.738, 172.368, 90, 90, 90
R / Rfree (%)	18.9 / 21.9

The binding sites of Arsenic atom in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood (pdb code 8pxu). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 4 binding sites of Arsenic where determined in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood, PDB code: 8pxu:
Jump to Arsenic binding site number: 1; 2; 3; 4;

Arsenic binding site 1 out of 4 in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood within 5.0Å range: probe atom residue distance (Å) B Occ A:As801 b:127.0 occ:1.00 AS A:CAC801 0.0 127.0 1.0 O2 A:CAC801 1.7 55.5 1.0 O1 A:CAC801 1.7 69.4 1.0 C2 A:CAC801 2.0 73.9 1.0 C1 A:CAC801 2.0 62.6 1.0 OE2 A:GLU467 3.6 50.8 1.0 O A:HOH1151 3.8 41.5 1.0 NH2 A:ARG159 4.0 48.4 1.0 O A:HOH954 4.1 45.0 1.0 NH1 A:ARG159 4.2 47.5 1.0 O A:HOH1012 4.3 50.6 1.0 CD2 A:TRP465 4.3 42.9 1.0 CE3 A:TRP465 4.4 42.7 1.0 O A:HOH936 4.4 51.7 1.0 CE2 A:TRP465 4.5 41.3 1.0 O A:HOH969 4.5 39.7 1.0 CZ A:ARG159 4.6 47.0 1.0 CG A:TRP465 4.6 39.9 1.0 CD A:GLU467 4.6 47.4 1.0 CZ3 A:TRP465 4.7 41.8 1.0 CZ2 A:TRP465 4.8 43.0 1.0 OE1 A:GLU467 4.8 43.5 1.0 CH2 A:TRP465 4.9 44.0 1.0 NE1 A:TRP465 4.9 43.1 1.0

Arsenic binding site 2 out of 4 in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood within 5.0Å range: probe atom residue distance (Å) B Occ B:As701 b:80.4 occ:1.00 AS B:CAC701 0.0 80.4 1.0 O2 B:CAC701 1.7 64.0 1.0 O1 B:CAC701 1.7 68.1 1.0 C2 B:CAC701 2.0 48.3 1.0 C1 B:CAC701 2.0 62.5 1.0 OE2 B:GLU467 3.3 39.2 1.0 O B:HOH891 3.5 41.2 1.0 NH2 B:ARG159 4.1 38.0 1.0 NH1 B:ARG159 4.1 35.7 1.0 CD2 B:TRP465 4.1 33.7 1.0 C2 B:CAC702 4.1 70.8 1.0 CG B:TRP465 4.2 34.7 1.0 O B:HOH823 4.2 38.7 1.0 CD B:GLU467 4.2 40.6 1.0 CE3 B:TRP465 4.4 33.1 1.0 OE1 B:GLU467 4.4 35.8 1.0 CE2 B:TRP465 4.5 34.9 1.0 CZ B:ARG159 4.6 42.9 1.0 CD1 B:TRP465 4.6 35.8 1.0 CB B:TRP465 4.6 32.3 1.0 NE1 B:TRP465 4.7 36.2 1.0 O B:HOH843 4.7 40.6 1.0 O B:HOH937 4.8 50.0 1.0 O2 B:CAC702 4.9 68.2 1.0 CZ3 B:TRP465 4.9 37.6 1.0

Arsenic binding site 3 out of 4 in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood within 5.0Å range: probe atom residue distance (Å) B Occ B:As702 b:117.5 occ:1.00 AS B:CAC702 0.0 117.5 1.0 O1 B:CAC702 1.8 86.7 1.0 O2 B:CAC702 1.8 68.2 1.0 C1 B:CAC702 1.9 52.9 1.0 C2 B:CAC702 2.0 70.8 1.0 OH B:TYR426 3.8 39.2 1.0 C2 B:CAC701 4.0 48.3 1.0 OD2 B:ASP320 4.2 48.9 1.0 CB B:ASP320 4.2 39.5 1.0 CG B:ASP320 4.3 48.7 1.0 CD1 B:TRP400 4.6 39.7 1.0 O B:HOH960 4.8 49.0 1.0 NE1 B:TRP400 4.8 40.3 1.0 NE1 B:TRP371 4.8 38.3 1.0 CG B:TRP400 4.9 39.1 1.0 CZ B:TYR426 4.9 40.6 1.0 CZ2 B:TRP465 4.9 35.7 1.0 OD1 B:ASP320 5.0 43.1 1.0 CD1 B:TRP371 5.0 38.6 1.0

Arsenic binding site 4 out of 4 in the Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of Targeting Extended Blood Antigens By Akkermansia Muciniphila Enzymes Unveils A Missing Link For Generating Universal Donor Blood within 5.0Å range: probe atom residue distance (Å) B Occ C:As701 b:123.0 occ:1.00 AS C:CAC701 0.0 123.0 1.0 O2 C:CAC701 1.7 60.7 1.0 O1 C:CAC701 1.7 87.2 1.0 C2 C:CAC701 1.9 64.2 1.0 C1 C:CAC701 2.0 75.1 1.0 OH C:TYR426 3.7 42.4 1.0 O C:HOH805 3.9 66.0 1.0 OD2 C:ASP320 4.2 48.0 1.0 O C:HOH841 4.3 42.6 1.0 CG C:ASP320 4.4 47.7 1.0 CB C:ASP320 4.5 38.8 1.0 CZ2 C:TRP465 4.7 43.1 1.0 CD1 C:TRP400 4.7 41.8 1.0 CZ C:TYR426 4.8 42.6 1.0 NE1 C:TRP371 4.8 37.5 1.0 CG C:TRP400 4.8 48.2 1.0 NE1 C:TRP400 4.9 44.8 1.0 CE2 C:TYR426 4.9 43.7 1.0 CE2 C:TRP371 5.0 39.1 1.0

M.Jensen, L.Stenfelt, J.R.Hagman, M.J.Pichler, J.Weikum, T.S.Nielsen, A.Hult, J.P.Morth, M.L.Olsson, M.Abou Hachem. Akkermansia Muciniphila Exoglycosidases Target Extended Blood Group Antigens to Generate Abo-Universal Blood Nature Microbiology 2024.