Arsenic in PDB 8ttt: Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140)

The structure of Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140), PDB code: 8ttt was solved by Q.Guo, K.-E.Chen, B.M.Collins, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.95 / 2.35
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	37.567, 74.371, 105.229, 90, 90, 90
R / Rfree (%)	19.1 / 25.1

The binding sites of Arsenic atom in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140) (pdb code 8ttt). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140), PDB code: 8ttt:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140) within 5.0Å range: probe atom residue distance (Å) B Occ A:As487 b:108.0 occ:1.00 AS A:CAF487 0.0 108.0 1.0 O1 A:CAF487 1.6 74.5 1.0 CE1 A:CAF487 2.0 76.9 1.0 CE2 A:CAF487 2.0 64.0 1.0 SG A:CAF487 2.3 59.3 1.0 CB A:CAF487 3.2 39.7 1.0 CE A:LYS501 4.2 54.4 1.0 NZ A:LYS501 4.2 55.0 1.0 CB A:ASP480 4.5 48.4 1.0 OD2 A:ASP480 4.6 65.0 1.0 CG A:LYS501 4.7 46.6 1.0 CA A:CAF487 4.7 39.9 1.0 CD A:LYS501 4.8 51.3 1.0 O A:THR479 4.8 44.6 1.0 CE3 A:TRP499 4.9 42.6 1.0 CG A:ASP480 4.9 56.2 1.0

Arsenic binding site 2 out of 2 in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Structure of SNX27 Ferm Complexed with FAM21A Repeat 15 (1124-1140) within 5.0Å range: probe atom residue distance (Å) B Occ A:As519 b:82.0 occ:1.00 AS A:CAF519 0.0 82.0 1.0 O1 A:CAF519 1.6 58.2 1.0 CE2 A:CAF519 2.0 71.3 1.0 CE1 A:CAF519 2.0 49.5 1.0 SG A:CAF519 2.3 43.9 1.0 CB A:CAF519 3.4 38.8 1.0 C A:CAF519 3.8 38.4 1.0 N A:GLU520 3.9 36.3 1.0 O A:CAF519 3.9 40.9 1.0 CA A:CAF519 4.2 35.8 1.0 C1 A:PEG604 4.2 48.3 1.0 CG A:GLU520 4.3 38.7 1.0 NH1 A:ARG516 4.3 46.4 1.0 CA A:GLU520 4.4 38.6 1.0 O1 A:PEG604 4.5 42.4 1.0 CD1 A:TRP523 4.6 44.2 1.0 CD A:ARG516 4.6 33.7 1.0 CZ A:ARG516 4.6 40.1 1.0 NE A:ARG516 4.7 35.4 1.0 O A:ARG516 4.9 35.1 1.0 CB A:GLU520 5.0 32.5 1.0

Q.Guo, K.E.Chen, M.Gimenez-Andres, A.P.Jellett, Y.Gao, B.Simonetti, M.Liu, C.M.Danson, K.J.Heesom, P.J.Cullen, B.M.Collins. Structural Basis For Coupling of the Wash Subunit FAM21 with the Endosomal SNX27-Retromer Complex. Proc.Natl.Acad.Sci.Usa V. 121 41121 2024.
ISSN: ESSN 1091-6490
PubMed: 39116126
DOI: 10.1073/PNAS.2405041121