Arsenic in PDB 2ilz: Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

Enzymatic activity of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

All present enzymatic activity of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+:
2.7.7.48;

Protein crystallography data

The structure of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+, PDB code: 2ilz was solved by A.A.Thompson, O.B.Peersen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	27.30 / 2.50
*Space group*	P 6₅
*Cell size a, b, c (Å), α, β, γ (°)*	128.159, 128.159, 112.610, 90.00, 90.00, 120.00
*R / R_free (%)*	23 / 25.5

Other elements in 2ilz:

The structure of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ also contains other interesting chemical elements:

Manganese	(Mn)	2 atoms
Sodium	(Na)	2 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ (pdb code 2ilz). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 4 binding sites of Arsenic where determined in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+, PDB code: 2ilz:
Jump to Arsenic binding site number: 1; 2; 3; 4;

Arsenic binding site 1 out of 4 in 2ilz

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Arsenic Binding Sites List in 2ilz

Arsenic binding site 1 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As96 b:86.2 occ:1.00	AS	A:CAS96	0.0	86.2	1.0
	CE2	A:CAS96	2.2	83.8	1.0
	CE1	A:CAS96	2.3	84.5	1.0
	SG	A:CAS96	2.3	81.9	1.0
	CB	A:CAS96	3.1	77.3	1.0
	OD2	A:ASP99	4.0	73.3	1.0
	CG	A:ASP99	4.4	72.0	1.0
	CA	A:CAS96	4.6	75.4	1.0
	OD1	A:ASP99	4.6	73.0	1.0
	CB	A:GLU98	4.9	76.9	1.0
	O	A:CAS96	5.0	75.0	1.0

Arsenic binding site 2 out of 4 in 2ilz

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Arsenic Binding Sites List in 2ilz

Arsenic binding site 2 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As212 b:52.0 occ:1.00	AS	A:CAS212	0.0	52.0	1.0
	CE2	A:CAS212	2.2	47.9	1.0
	CE1	A:CAS212	2.2	52.9	1.0
	SG	A:CAS212	2.3	43.5	1.0
	CB	A:CAS212	3.2	38.8	1.0
	O	A:ALA209	3.5	31.5	1.0
	CD1	A:LEU374	3.6	43.6	1.0
	O	A:CAS212	3.6	35.4	1.0
	CA	A:CAS212	3.9	36.2	1.0
	C	A:CAS212	3.9	34.5	1.0
	N	A:CAS212	4.0	36.7	1.0
	CE2	A:TYR326	4.2	43.4	1.0
	CG	A:PRO214	4.3	29.5	1.0
	CD2	A:TYR326	4.3	40.1	1.0
	CD	A:PRO214	4.3	30.0	1.0
	C	A:ALA209	4.5	30.5	1.0
	N	A:ASP213	4.8	33.7	1.0
	CB	A:ALA209	4.8	28.9	1.0
	CZ	A:TYR326	4.9	42.9	1.0
	N	A:GLY211	4.9	34.6	1.0
	C	A:GLY211	4.9	35.8	1.0
	CG	A:LEU374	5.0	42.5	1.0
	O	A:HOH525	5.0	54.3	1.0

Arsenic binding site 3 out of 4 in 2ilz

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Arsenic Binding Sites List in 2ilz

Arsenic binding site 3 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 3 of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As281 b:47.6 occ:1.00	AS	A:CAS281	0.0	47.6	1.0
	CE2	A:CAS281	2.2	45.0	1.0
	CE1	A:CAS281	2.2	46.8	1.0
	SG	A:CAS281	2.2	41.1	1.0
	CB	A:CAS281	3.1	46.3	1.0
	CA	A:CAS281	3.8	48.2	1.0
	O	A:SER271	3.9	49.2	1.0
	C	A:SER271	4.1	50.8	1.0
	CA	A:HIS272	4.2	51.9	1.0
	N	A:HIS272	4.3	51.6	1.0
	CZ2	A:TRP5	4.3	38.4	1.0
	CB	A:HIS272	4.3	51.8	1.0
	C	A:CAS281	4.7	48.3	1.0
	CG	A:HIS272	4.7	51.4	1.0
	N	A:VAL282	4.8	46.7	1.0
	CD2	A:HIS272	4.8	51.8	1.0
	CE2	A:TRP5	4.9	39.7	1.0
	N	A:CAS281	4.9	49.5	1.0
	CA	A:SER271	4.9	50.3	1.0
	CH2	A:TRP5	5.0	39.5	1.0

Arsenic binding site 4 out of 4 in 2ilz

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Arsenic Binding Sites List in 2ilz

Arsenic binding site 4 out of 4 in the Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+

Mono view

Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 4 of Crystal Structure of Poliovirus Polymerase Complexed with Gtp and MN2+ within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:As290 b:75.6 occ:1.00	AS	A:CAS290	0.0	75.6	1.0
	CE2	A:CAS290	2.2	73.3	1.0
	CE1	A:CAS290	2.3	74.0	1.0
	SG	A:CAS290	2.3	70.6	1.0
	CB	A:CAS290	3.1	65.1	1.0
	SD	A:MET187	3.7	58.6	1.0
	CD2	A:LEU268	3.8	37.5	1.0
	CB	A:SER179	4.1	49.8	1.0
	CA	A:CAS290	4.2	61.7	1.0
	CG	A:LEU268	4.4	40.3	1.0
	CD2	A:LEU154	4.6	47.4	1.0
	CE	A:MET187	4.7	59.3	1.0
	OG	A:SER179	4.8	48.5	1.0
	N	A:SER291	4.8	59.1	1.0
	CB	A:ASP183	4.9	58.6	1.0
	CD2	A:TYR267	4.9	67.2	1.0

Reference:

A.A.Thompson, R.A.Albertini, O.B.Peersen. Stabilization of Poliovirus Polymerase By Ntp Binding and Fingers-Thumb Interactions. J.Mol.Biol. V. 366 1459 2007.
ISSN: ISSN 0022-2836
PubMed: 17223130
DOI: 10.1016/J.JMB.2006.11.070

Page generated: Sun Jul 6 23:10:10 2025

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