Arsenic in PDB 4c2a: Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha

The structure of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha, PDB code: 4c2a was solved by M.A.Blenner, X.Dong, T.A.Springer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	48.446 / 2.08
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	89.060, 89.060, 124.520, 90.00, 90.00, 120.00
R / Rfree (%)	16.05 / 18.9

The structure of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha also contains other interesting chemical elements:

Calcium

(Ca)

1 atom

The binding sites of Arsenic atom in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha (pdb code 4c2a). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha, PDB code: 4c2a:

Arsenic binding site 1 out of 1 in the Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of High-Affinity Von Willebrand Factor A1 Domain with R1306Q and I1309V Mutations in Complex with High Affinity Gpib Alpha within 5.0Å range: probe atom residue distance (Å) B Occ A:As2468 b:0.2 occ:1.00 AS A:CAC2468 0.0 0.2 1.0 O2 A:CAC2468 1.7 79.0 1.0 O1 A:CAC2468 1.7 0.3 1.0 C1 A:CAC2468 2.0 66.4 1.0 C2 A:CAC2468 2.0 0.5 1.0 NH2 A:ARG1450 3.8 73.1 1.0 ND1 A:HIS1268 4.2 41.5 1.0 O A:HOH2009 4.4 44.9 1.0 O A:LEU1267 4.4 71.7 1.0 CA A:HIS1268 4.7 47.1 1.0 CZ A:ARG1450 4.9 60.7 1.0 CE1 A:HIS1268 4.9 45.6 1.0 O A:HOH2025 5.0 54.3 1.0

M.A.Blenner, X.Dong, T.A.Springer. Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem. V. 289 5565 2014.
ISSN: ISSN 0021-9258
PubMed: 24391089
DOI: 10.1074/JBC.M113.511220