Atomistry » Arsenic » PDB 6wri-6xl2 » 6xha
Atomistry »
  Arsenic »
    PDB 6wri-6xl2 »
      6xha »

Arsenic in PDB 6xha: Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf

Enzymatic activity of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf

All present enzymatic activity of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf:
2.7.11.1; 3.6.5.2;

Protein crystallography data

The structure of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf, PDB code: 6xha was solved by T.H.Tran, A.H.Chan, S.Dharmaiah, D.K.Simanshu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.30 / 2.87
Space group P 6 2 2
Cell size a, b, c (Å), α, β, γ (°) 132.1, 132.1, 90.17, 90, 90, 120
R / Rfree (%) 21.7 / 26.9

Other elements in 6xha:

The structure of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Zinc (Zn) 2 atoms
Chlorine (Cl) 2 atoms

Arsenic Binding Sites:

The binding sites of Arsenic atom in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf (pdb code 6xha). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf, PDB code: 6xha:

Arsenic binding site 1 out of 1 in 6xha

Go back to Arsenic Binding Sites List in 6xha
Arsenic binding site 1 out of 1 in the Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Crystal Structure of Kras-G12V (Gmppnp-Bound) in Complex with Ras- Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf within 5.0Å range:
probe atom residue distance (Å) B Occ
B:As95

b:63.1
occ:0.67
 AS B:CAF95 0.0 63.1 0.7
O1 B:CAF95 1.7 71.8 0.4
CE1 B:CAF95 1.9 62.6 1.0
CE2 B:CAF95 1.9 67.0 0.5
SG B:CAF95 2.3 59.1 0.8
CB B:CAF95 3.2 62.7 0.8
CD1 B:LEU136 3.9 49.2 1.0
CG B:LEU136 3.9 49.0 1.0
CD B:PRO135 4.1 55.5 1.0
CD2 B:LEU136 4.3 43.6 1.0
CG B:PRO135 4.4 62.8 1.0
CB B:VAL134 4.4 50.4 1.0
CA B:CAF95 4.5 59.8 0.9
CG1 B:VAL134 4.7 51.5 1.0
N B:PRO135 4.8 57.4 1.0
CB B:GLN92 5.0 83.0 1.0

Reference:

T.H.Tran, A.H.Chan, S.Dharmaiah, D.K.Simanshu. Crystal Structure of Wild-Type Kras (Gmppnp-Bound) in Complex with Ras-Binding Domain (Rbd) and Cysteine-Rich Domain (Crd) of RAF1/Craf (Crystal Form I) Nat Commun 2020.
ISSN: ESSN 2041-1723
Page generated: Mon Jul 7 00:52:18 2025

Last articles

Cl in 4AGR
Cl in 4AGG
Cl in 4ACF
Cl in 4AGA
Cl in 4AF8
Cl in 4AC2
Cl in 4ADG
Cl in 4ADN
Cl in 4A97
Cl in 4ABV
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy